Sugi Predict

Sugi Predict / Compounds / SCHEMBL409564

SCHEMBL409564

SCHEMBL409564

[O]C(=O)c1ccccc1Br

nearest known ligand 0.54

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 3/20 0.48
▸ NPC1 O15118 1/20 0.48
▸ RAB9A P51151 1/20 0.48
▸ ALDH1A1 P00352 6/20 0.47
▸ LMNA P02545 2/20 0.47
▸ TP53 P04637 1/20 0.47
▸ MEN1 O00255 2/20 0.46
▸ KMT2A Q03164 2/20 0.46
▸ ELANE P08246 1/20 0.46
▸ POLB P06746 1/20 0.44
▸ ALOX15 P16050 1/20 0.43
▸ SMN1; SMN2 Q16637 2/20 0.43
▸ HSD17B10 Q99714 1/20 0.43
▸ PRNP P04156 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1802165 0.81 CES2 (0.50) HPGDNPC1RAB9AALDH1A1LMNA
SCHEMBL1681866 0.81 PRNP (0.53) HPGDNPC1RAB9AALDH1A1MEN1
SCHEMBL29470997 0.81 PRNP (0.53) HPGDNPC1RAB9AALDH1A1MEN1
SCHEMBL8678737 0.80 ALDH1A1 (0.52) HPGDNPC1RAB9AALDH1A1LMNA
SCHEMBL4652941 0.80 ALDH1A1 (0.56) HPGDALDH1A1TP53POLBALOX15
SCHEMBL3257688 0.79 HPGD (0.48) HPGDNPC1RAB9AALDH1A1MEN1
SCHEMBL49806 0.79 ALDH1A1 (0.65) HPGDNPC1RAB9AALDH1A1MEN1
SCHEMBL9679485 0.79 PRNP (0.57) HPGDNPC1RAB9AALDH1A1MEN1
SCHEMBL3844423 0.79 PRNP (0.57) HPGDNPC1RAB9AALDH1A1MEN1
SCHEMBL2112435 0.77 ALDH1A1 (0.62) HPGDNPC1RAB9AALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110184173-A1 Pyripyropene Derivatives Having An ACAT2-Inhibiting Activity THE KITASATO INSTITUTE (JP) 2011-07-28 — — US claimed
EP-2228376-A1 PYRIPYROPENE DERIVATIVE HAVING ACAT2-INHIBITING ACTIVITY The Kitasato Institute (JP) 2010-09-15 — — EP claimed
US-20100179217-A1 THERAPEUTIC COMPOUNDS UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 2010-07-15 — — US claimed
US-7728001-B2 Opioid receptor ligands and methods for their preparation UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 2010-06-01 — — US claimed
US-20090088466-A1 OPIOID RECEPTOR LIGANDS UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 2009-04-02 — — US claimed
WO-2008055261-A2 THERAPEUTIC COMPOUNDS UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 2008-05-08 — — WO claimed
WO-2006138589-A2 OPIOID RECEPTOR LIGANDS UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 2006-12-28 — — WO claimed
WO-2006031782-A2 SALVINORIN DERIVATIVES AS OPIOID RECEPTOR LIGANDS UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 2006-03-23 — — WO claimed
US-20060058264-A1 Opioid receptor ligands and methods for their preparation THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES 2006-03-16 — — US claimed
US-4772292-A Mixture of yellow disperse dyestuffs containing pyridone disazo dye CASSELLA AKTIENGESELLSCHAFT (DE) 1988-09-20 — — US claimed
WO-2022065424-A1 CARCINOSTATIC AGENT, CARCINOGENESIS INHIBITOR AND LIFE-PROLONGING AGENT, COMPRISING NOVEL COMPOUND WITH MTORC1 INHIBITORY EFFECT 国立研究開発法人理化学研究所 2022-03-31 — — WO disclosed
EP-3564232-B1 BMP-SIGNAL-INHIBITING COMPOUND RIKEN (JP) 2022-01-26 — — EP disclosed
US-10954216-B2 BMP-signal-inhibiting compound RIKEN (JP) 2021-03-23 — — US disclosed
US-20190337926-A1 BMP-SIGNAL-INHIBITING COMPOUND RIKEN (JP) 2019-11-07 — — US disclosed
EP-3564232-A1 BMP-SIGNAL-INHIBITING COMPOUND Riken (JP) 2019-11-06 — — EP disclosed
EP-0319316-A2 Griseolic acid monoesters, their preparation and use SANKYO COMPANY LIMITED (JP) 1989-06-07 — — EP disclosed
EP-0251827-A2 New cyclic ether derivatives, their preparation and their use Sankyo Company Limited (JP) 1988-01-07 — — EP disclosed
EP-0113293-B1 LIQUID CRYSTALS FAMILY WITH A SMECTIC A PHASE, AND PROCESS FOR ITS PREPARATION THOMSON-CSF (FR) 1986-08-20 — — EP disclosed
EP-0113293-A1 Liquid crystals family with a smectic A phase, and process for its preparation THOMSON-CSF (FR) 1984-07-11 — — EP disclosed
US-4113939-A HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1978-09-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100179217-A1 THERAPEUTIC COMPOUNDS OPRL1, OPRK1, OPRM1 HPGD 898/4885NPC1 914/4885RAB9A 1806/4885
US-10954216-B2 BMP-signal-inhibiting compound BMP1, BMP2, BMP4 HPGD 1295/4885NPC1 2815/4885RAB9A 1809/4885
US-20190337926-A1 BMP-SIGNAL-INHIBITING COMPOUND BMP1, BMP2, BMPR2 HPGD 1101/4885NPC1 2975/4885RAB9A 1632/4885
US-20110184173-A1 Pyripyropene Derivatives Having An ACAT2-Inhibiting Activity ACAT2, ACAT1, AGPAT2 HPGD 1060/4885NPC1 266/4885RAB9A 3972/4885
US-20090088466-A1 OPIOID RECEPTOR LIGANDS OPRL1, OPRK1, OPRM1 HPGD 1010/4885NPC1 1024/4885RAB9A 1475/4885
US-20060058264-A1 Opioid receptor ligands and methods for their preparation OPRL1, OPRM1, OPRK1 HPGD 902/4885NPC1 813/4885RAB9A 1854/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.