Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | KIF11 | P52732 | 8/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.47 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6007665 | 0.89 | ALDH1A1 (0.70) | ALDH1A1KDM4EMAPTHCRTR1RAB9A | |
| SCHEMBL6009615 | 0.83 | ALDH1A1 (0.63) | ALDH1A1KDM4EMAPTHCRTR1RAB9A | |
| SCHEMBL70604 | 0.83 | ALDH1A1 (0.81) | ALDH1A1KDM4EMAPTHCRTR1RAB9A | |
| SCHEMBL6009670 | 0.82 | KDM4E (0.84) | ALDH1A1KDM4EMAPTHCRTR1RAB9A | |
| SCHEMBL8795255 | 0.82 | ALOX15 (0.57) | MAPT | |
| SCHEMBL8540507 | 0.81 | KDM4E (0.60) | ALDH1A1KDM4EMAPTRAB9AMEN1 | |
| SCHEMBL11092135 | 0.80 | KIF11 (0.44) | ALDH1A1KDM4EMAPTHCRTR1MEN1 | |
| SCHEMBL11806405 | 0.80 | KDM4E (0.50) | ALDH1A1KDM4EMAPTHCRTR1RAB9A | |
| SCHEMBL29777 | 0.80 | MAPT (0.48) | ALDH1A1KDM4EMAPTKIF11HPGD | |
| SCHEMBL668192 | 0.79 | CA12 (0.61) | KDM4EMAPTRAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090170882-A1 | Methods and compositions | CYTOKINETICS, INCORPORATED | 2009-07-02 | — | — | US | disclosed |
| US-20090170882-A1 | Methods and compositions | CYTOKINETICS, INCORPORATED | 2009-07-02 | — | — | US | disclosed |
| EP-1771176-A2 | METHODS AND COMPOSITIONS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-11 | — | — | EP | disclosed |
| WO-2006005063-A2 | METHODS AND COMPOSITIONS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170882-A1 | Methods and compositions | KIF5B, KIF5C, KIF2C | ALDH1A1 3367/4885KDM4E 2332/4885MAPT 47/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.