Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.38 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.36 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.36 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KRAS | P01116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4173661 | 0.84 | PDK1 (0.40) | DRD4CYP2C9ALDH1A1CYP2C19PDK1 | |
| SCHEMBL4180132 | 0.82 | HTR1A (0.44) | PDK1 | |
| SCHEMBL3172078 | 0.82 | MEN1 (0.43) | ALDH1A1SCN9AMEN1KMT2A | |
| SCHEMBL4178403 | 0.77 | TRPC3 (0.41) | CYP2C9ALDH1A1CYP2C19TRPC3TRPC6 | |
| SCHEMBL4176347 | 0.76 | ALDH1A1 (0.43) | CYP2C9ALDH1A1CYP2C19TRPC3TRPC6 | |
| SCHEMBL4176180 | 0.76 | ALDH1A1 (0.43) | CYP2C9ALDH1A1CYP2C19TRPC3TRPC6 | |
| SCHEMBL4172610 | 0.73 | SCD5 (0.41) | CYP2C9ALDH1A1CYP2C19MEN1KMT2A | |
| SCHEMBL4171049 | 0.73 | ALDH1A1 (0.43) | CYP2C9ALDH1A1CYP2C19SCN9AMEN1 | |
| SCHEMBL4178167 | 0.73 | TRPC3 (0.54) | ALDH1A1TRPC3TRPC6SCN9AKDM5A | |
| SCHEMBL4167596 | 0.73 | TRPC3 (0.44) | CYP2C9ALDH1A1CYP2C19TRPC3TRPC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130072471-A1 | Inhibitors of Ion Channels | MARRON BRIAN EDWARD (US) | 2013-03-21 | — | — | US | disclosed |
| US-8357711-B2 | Heterocyclic sulfonamides as inhibitors of ion channels | PFIZER LIMITED (GB) | 2013-01-22 | — | — | US | disclosed |
| US-20090143358-A1 | INHIBITORS OF ION CHANNELS | ICAGEN, INC. (US) | 2009-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130072471-A1 | Inhibitors of Ion Channels | TRPV1, TRPV5, TRPA1 | DRD4 3922/4885CYP2C9 1382/4885ALDH1A1 3113/4885 |
| US-20090143358-A1 | INHIBITORS OF ION CHANNELS | TRPV1, TRPV5, TRPA1 | DRD4 3922/4885CYP2C9 1382/4885ALDH1A1 3113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.