Water

Water

SCHEMBL4188957

CCOCCOCc1ccco1.CCOCCOCc1ccco1.CCOCCOCc1ccco1.CCOCCOCc1ccco1.O

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.47
CYP2D6 P10635 1/20 0.43
GAA P10253 1/20 0.42
MAPT P10636 4/20 0.40
HTT P42858 2/20 0.38
POLB P06746 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
SLC1A3 P43003 1/20 0.36
SLC1A2 P43004 1/20 0.36
SLC1A1 P43005 1/20 0.36
HPGD P15428 4/20 0.36
HSD17B10 Q99714 2/20 0.36
TP53 P04637 1/20 0.36
TSHR P16473 1/20 0.35
PER2 O15055 1/20 0.35
CRY1 Q16526 1/20 0.35
CRY2 Q49AN0 1/20 0.35
MAPK1 P28482 1/20 0.35
TDP1 Q9NUW8 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20324523 0.98 ALDH1A1 (0.49) ALDH1A1CYP2D6GAAMAPTHTT
SCHEMBL20324519 0.96 ALDH1A1 (0.47) ALDH1A1CYP2D6GAAMAPTHTT
SCHEMBL20324517 0.96 ALDH1A1 (0.47) ALDH1A1CYP2D6GAAMAPTHTT
Water SCHEMBL11881132 0.90 ALDH1A1 (0.52) ALDH1A1CYP2D6GAAMAPTHTT
SCHEMBL1152092 0.88
SCHEMBL15087211 0.88 ALDH1A1 (0.52) ALDH1A1CYP2D6GAAMAPTHTT
SCHEMBL20324518 0.85 ALDH1A1 (0.47) ALDH1A1CYP2D6GAAMAPTHTT
SCHEMBL10942355 0.85 ALDH1A1 (0.50) ALDH1A1CYP2D6GAAMAPTHTT
SCHEMBL8806778 0.83 ALDH1A1 (0.49) ALDH1A1CYP2D6GAAMAPTHTT
SCHEMBL20324528 0.81 ALDH1A1 (0.47) ALDH1A1CYP2D6GAAMAPTHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090042848-A1 COPPER COMPLEXES LAY PETER 2009-02-12 US disclosed
US-20080039522-A1 Composition Containing a Complex Comprising a Metal Ion and a Carboxylate Ligand Having Anti-Inflammatory Activity MEDICAL THERAPIES LIMITED (AU) 2008-02-14 US disclosed
EP-1868995-A1 COPPER COMPLEXES MEDICAL THERAPIES LIMITED (AU) 2007-12-26 EP disclosed
WO-2007109844-A1 ANTI-INFLAMMATORY METAL COMPLEXES MEDICAL THERAPIES LIMITED (AU) 2007-10-04 WO disclosed
WO-2007109843-A1 METAL COMPLEXES HAVING ANTI-INFLAMMATORY ACTIVITY MEDICAL THERAPIES LIMITED (AU) 2007-10-04 WO disclosed
EP-1734945-A4 A COMPOSITION CONTAINING A COMPLEX COMPRISING A METAL ION AND A CARBOXYLATE LIGAND HAVING ANTI-INFLAMMATORY ACTIVITY MEDICAL THERAPIES LTD (AU) 2007-10-03 EP disclosed
EP-1734945-A1 A COMPOSITION CONTAINING A COMPLEX COMPRISING A METAL ION AND A CARBOXYLATE LIGAND HAVING ANTI-INFLAMMATORY ACTIVITY THE UNIVERSITY OF SYDNEY (AU) 2006-12-27 EP disclosed
WO-2006099685-A1 METHOD FOR THE PROPHYLAXIS OR TREATMENT OF CARCINOMAS MEDICAL THERAPIES LIMITED (AU) 2006-09-28 WO disclosed
WO-2006099684-A1 COPPER COMPLEXES MEDICAL THERAPIES LIMITED (AU) 2006-09-28 WO disclosed
WO-2006099677-A1 METAL COMPLEXES MEDICAL THERAPIES LIMITED (AU) 2006-09-28 WO disclosed
WO-2005094809-A1 A COMPOSITION CONTAINING A COMPLEX COMPRISING A METAL ION AND A CARBOXYLATE LIGAND HAVING ANTI-INFLAMMATORY ACTIVITY MEDICAL THERAPIES LIMITED (AU) 2005-10-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090042848-A1 COPPER COMPLEXES SOD1, SOD3, CCL2 ALDH1A1 444/4885CYP2D6 520/4885GAA 2360/4885
US-20080039522-A1 Composition Containing a Complex Comprising a Metal Ion and a Carboxylate Ligand Having Anti-Inflammatory Activity MIF, TNF, LITAF ALDH1A1 1481/4885CYP2D6 2292/4885GAA 1199/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.