SCHEMBL421633

SCHEMBL421633

O=[N+]([O-])/C=C/c1ccc(Br)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FBP1 P09467 12/20 0.64
EGFR P00533 2/20 0.64
ALDH1A1 P00352 3/20 0.58
LMNA P02545 3/20 0.58
MAPT P10636 2/20 0.58
SMN1; SMN2 Q16637 2/20 0.58
VCP P55072 2/20 0.58
TLR4 O00206 1/20 0.55
TLR2 O60603 1/20 0.55
ABL1 P00519 1/20 0.53
ABL2 P42684 1/20 0.53
MEN1 O00255 2/20 0.53
KMT2A Q03164 2/20 0.53
S1PR4 O95977 1/20 0.51
HSP90AA1 P07900 1/20 0.51
HPGD P15428 1/20 0.51
S1PR1 P21453 1/20 0.51
MAPK1 P28482 1/20 0.51
CCR6 P51684 1/20 0.51
NPSR1 Q6W5P4 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL421634 1.00 FBP1 (0.64) FBP1EGFRALDH1A1LMNAMAPT
SCHEMBL6910818 0.89 FBP1 (0.78) FBP1EGFRALDH1A1LMNAMAPT
SCHEMBL6910815 0.89 FBP1 (0.78) FBP1EGFRALDH1A1LMNAMAPT
SCHEMBL1681205 0.78 FBP1 (1.00) FBP1EGFRALDH1A1LMNAMAPT
SCHEMBL366121 0.78 FBP1 (1.00) FBP1EGFRALDH1A1LMNAMAPT
SCHEMBL219464 0.78 FBP1 (1.00) FBP1EGFRALDH1A1LMNAMAPT
SCHEMBL366122 0.78 FBP1 (1.00) FBP1EGFRALDH1A1LMNAMAPT
SCHEMBL1681206 0.78 FBP1 (1.00) FBP1EGFRALDH1A1LMNAMAPT
SCHEMBL2077031 0.78 FBP1 (1.00) FBP1EGFRALDH1A1LMNAMAPT
SCHEMBL2077034 0.78 FBP1 (1.00) FBP1EGFRALDH1A1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 156 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119678922-A Application of nitrostyrenes compound in preventing, controlling or resisting plant pathogenic nematodes and preparation thereof 广西田园生化股份有限公司 2025-03-25 CN claimed
CN-118844436-A Application of nitrostyrene compound in preventing and treating plant diseases and food-borne pathogenic bacteria 广西田园生化股份有限公司 2024-10-29 CN claimed
CN-119678922-A Application of nitrostyrenes compound in preventing, controlling or resisting plant pathogenic nematodes and preparation thereof 广西田园生化股份有限公司 2025-03-25 CN disclosed
CN-119678922-A Application of nitrostyrenes compound in preventing, controlling or resisting plant pathogenic nematodes and preparation thereof 广西田园生化股份有限公司 2025-03-25 CN disclosed
CN-118844436-A Application of nitrostyrene compound in preventing and treating plant diseases and food-borne pathogenic bacteria 广西田园生化股份有限公司 2024-10-29 CN disclosed
CN-118844436-A Application of nitrostyrene compound in preventing and treating plant diseases and food-borne pathogenic bacteria 广西田园生化股份有限公司 2024-10-29 CN disclosed
CN-118420514-A Method for synthesizing 3- (2-nitro-1-aryl) -1H-indole derivative by using cyclopentadienyl titanium/Bronsted acid in synergistic catalysis mode 宁夏师范学院 2024-08-02 CN disclosed
US-20240166693-A1 METHODS AND COMPOUNDS FOR MODULATING MYOTONIC DYSTROPY 1 Design Therapeutics, Inc. 2024-05-23 US disclosed
EP-4259133-A1 METHODS AND COMPOUNDS FOR MODULATING MYOTONIC DYSTROPHY 1 Design Therapeutics, Inc. (US) 2023-10-18 EP disclosed
US-20230167073-A1 ARYL OR HETEROARYL DERIVATIVE TEIJIN PHARMA LIMITED (JP) 2023-06-01 US disclosed
CN-115996910-A Aryl or heteroaryl derivatives 帝人制药株式会社 2023-04-21 CN disclosed
US-20070105904-A1 3-(3-(4-(pyridin-2-yloxymethyl)-benzyl)-isoxazol-5-yl)-pyridin-2-ylamine; inhibiting fungal GPI biosynthesis thereby inhibiting expression of cell wall proteins and blocking cell wall assembly while preventing the fungus from attaching to cells EISAI R&D MANAGEMENT CO., LTD. (JP) 2007-05-10 US disclosed
CN-1882590-A Fused heterocyclic compounds as serotonin receptor modulators JOHNSON & JOHNSON (BE) 2006-12-20 CN disclosed
EP-1668014-A2 FUSED HETEROCYCLIC COMPOUNDS AS SEROTONIN RECEPTOR MODULATORS JANSSEN PHARMACEUTICA N.V. (BE) 2006-06-14 EP disclosed
WO-2006015827-A1 COMPOUNDS WHICH POTENTIATE GLUTAMATE RECEPTOR AND USES THEREOF IN MEDICINE GLAXO GROUP LIMITED (GB) 2006-02-16 WO disclosed
US-20050119295-A1 Fused heterocyclic compounds JANSSEN PHARMACEUTICA, N.V. (BE) 2005-06-02 US disclosed
WO-2005040169-A2 FUSED HETEROCYCLIC COMPOUNDS AS SEROTONIN RECEPTOR MODULATORS JANSSEN PHARMACEUTICA, N.V. (BE) 2005-05-06 WO disclosed
US-4148795-A Dithiocarbamate ester bactericides and fungicides AMERICAN CYANAMID COMPANY (US) 1979-04-10 US disclosed
US-4038288-A DITHIOCARBAMATE ESTER BACTERICIDES AND FUNGICIDES AMERICAN CYANAMID COMPANY (US) 1977-07-26 US disclosed
US-4011230-A DITHIOCARBAMATE ESTER BACTERICIDES AND FUNGICIDES AMERICAN CYANAMID COMPANY (US) 1977-03-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230167073-A1 ARYL OR HETEROARYL DERIVATIVE ARRB1, NR3C2, TRPC6 FBP1 3207/4885EGFR 591/4885ALDH1A1 3424/4885
US-20240166693-A1 METHODS AND COMPOUNDS FOR MODULATING MYOTONIC DYSTROPY 1 MTPN, DMPK, MBNL1 FBP1 2583/4885EGFR 4669/4885ALDH1A1 4267/4885
US-20050119295-A1 Fused heterocyclic compounds TPH1, HTR3A, HTR3B FBP1 1093/4885EGFR 4700/4885ALDH1A1 2953/4885
US-20070105904-A1 3-(3-(4-(pyridin-2-yloxymethyl)-benzyl)-isoxazol-5-yl)-pyridin-2-ylamine; inhibiting fungal GPI biosynthesis thereby inhibiting expression of cell wall proteins and blocking cell wall assembly while preventing the fungus from attaching to cells GPI, ERG28, MAN2A1 FBP1 426/4885EGFR 2087/4885ALDH1A1 3327/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.