Sugi Predict

Sugi Predict / Compounds / SCHEMBL423288

SCHEMBL423288

SCHEMBL423288

CC(C)c1cc(Cl)ccc1Cl

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TP53 P04637 4/20 0.50
▸ HTT P42858 2/20 0.50
▸ LMNA P02545 2/20 0.50
▸ GABRA1 P14867 1/20 0.50
▸ GABRB1 P18505 1/20 0.50
▸ TSHR P16473 4/20 0.42
▸ ALDH1A1 P00352 3/20 0.42
▸ CYP3A4 P08684 2/20 0.42
▸ HSD17B10 Q99714 2/20 0.42
▸ TDP1 Q9NUW8 2/20 0.42
▸ MEN1 O00255 3/20 0.40
▸ KMT2A Q03164 3/20 0.40
▸ MAPT P10636 1/20 0.40
▸ MAPK1 P28482 1/20 0.40
▸ NPSR1 Q6W5P4 1/20 0.40
▸ GCGR P47871 1/20 0.39
▸ KCNH2 Q12809 1/20 0.38
▸ CYP2A6 P11509 1/20 0.37
▸ S1PR4 O95977 1/20 0.37
▸ S1PR5 Q9H228 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10612899 0.85 TP53 (0.50) TP53HTTLMNAGABRA1GABRB1
SCHEMBL11501929 0.83 TP53 (0.48) TP53HTTLMNAGABRA1GABRB1
SCHEMBL12197660 0.82 GABRA1 (0.52) TP53HTTLMNAGABRA1GABRB1
SCHEMBL16954079 0.81 TP53 (0.47) TP53HTTLMNAGABRA1GABRB1
SCHEMBL8196904 0.81 TP53 (0.69) TP53HTTLMNAGABRA1GABRB1
SCHEMBL23046954 0.81 TP53 (0.47) TP53HTTLMNAGABRA1GABRB1
SCHEMBL16618296 0.81 TP53 (0.47) TP53HTTLMNAGABRA1GABRB1
SCHEMBL10980265 0.81 TP53 (0.47) TP53HTTLMNAGABRA1GABRB1
SCHEMBL20868991 0.81 TP53 (0.69) TP53HTTLMNAGABRA1GABRB1
SCHEMBL1125463 0.81 TP53 (0.47) TP53HTTLMNAGABRA1GABRB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 355 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0083685-B1 MANUFACTURE OF DIISOCYANATES AMERICAN CYANAMID COMPANY (US) 1985-03-06 — — EP claimed
EP-4479479-B1 SILPHENYLENE POLYMERS WACKER CHEMIE AG (DE) 2025-08-13 — — EP disclosed
CN-119256051-A Silicon phenylene Polymer 瓦克化学股份公司 2025-01-03 — — CN disclosed
EP-4479479-A1 SILPHENYLENE POLYMERS Wacker Chemie AG (DE) 2024-12-25 — — EP disclosed
CN-118271338-A Organic compound, application thereof and organic electroluminescent device 北京绿人科技有限责任公司 2024-07-02 — — CN disclosed
WO-2024103400-A1 POLYCYCLIC COMPOUND AS GPR75 ACTIVATOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND USE THEREOF 水木未来(北京)科技有限公司 2024-05-23 — — WO disclosed
US-11912668-B2 GCN2 and perk kinase inhibitors and methods of use thereof DECIPHERA PHARMACEUTICALS, LLC (US) 2024-02-27 — — US disclosed
US-11858880-B2 Anti-fungals compounds targeting the synthesis of fungal sphingolipids THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2024-01-02 — — US disclosed
US-11858880-B2 Anti-fungals compounds targeting the synthesis of fungal sphingolipids THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2024-01-02 — — US disclosed
US-20230399299-A1 ALDH-2 INHIBITOR COMPOUNDS AND METHODS OF USE AMYGDALA NEUROSCIENCES, INC. (US) 2023-12-14 — — US disclosed
US-20070015797-A1 Substituted acid derivatives useful as antidiabetic and antiobesity agents and method CHENG PETER T 2007-01-18 — — US disclosed
CN-1668557-A Method for producing chlorinated hydrocarbon having chlorinated tertiary carbon KANEGAFUCHI CHEMICAL IND (JP) 2005-09-14 — — CN disclosed
WO-2004039367-A1 PROLINE DERIVATIVES HAVING AFFINITY FOR THE CALCIUM CHANNEL ALPHA-2-DELTA SUBUNIT PFIZER LIMITED (GN) 2004-05-13 — — WO disclosed
EP-0322869-B1 PROCESS FOR SEPARATING DICHLOROCUMENE ISOMER TORAY INDUSTRIES, INC. (JP) 1992-09-09 — — EP disclosed
US-4922039-A Process for separating dichlorocumene isomer TORAY INDUSTRIES (JP) 1990-05-01 — — US disclosed
EP-0322869-A2 Process for separating dichlorocumene isomer TORAY INDUSTRIES, INC. (JP) 1989-07-05 — — EP disclosed
US-4760209-A Isopropylation, isomerization, bromination and dehydrobromination BAYER AKTIENGESELLSCHAFT (DE) 1988-07-26 — — US disclosed
US-4594467-A DEHYDROBROMINATING ALPH-BROMO-3,5-DICHLORO CUMENE WITH ALKALI METAL HYDROXIDE IN PRESENCE OF PHASE TRANSFER CATALYST BAYER AKTIENGESELLSCHAFT (DE) 1986-06-10 — — US disclosed
US-4219570-A Insect repellents and a method of repelling insects AJINOMOTO COMPANY, INCORPORATED (JP) 1980-08-26 — — US disclosed
US-4059642-A Preferential alkylation or acylation of meta-disubstituted benzenes THE DOW CHEMICAL COMPANY (US) 1977-11-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11858880-B2 Anti-fungals compounds targeting the synthesis of fungal sphingolipids ERG28, UGCG, DPM1 TP53 3293/4885HTT 4768/4885LMNA 3665/4885
US-11912668-B2 GCN2 and perk kinase inhibitors and methods of use thereof EIF2AK4, GCN1, MAPKAPK2 TP53 3755/4885HTT 727/4885LMNA 770/4885
US-20070015797-A1 Substituted acid derivatives useful as antidiabetic and antiobesity agents and method GPR119, LIPC, ACACA TP53 4801/4885HTT 2959/4885LMNA 320/4885
US-20230399299-A1 ALDH-2 INHIBITOR COMPOUNDS AND METHODS OF USE ALDH1A1, ALDH2, ALDH3A1 TP53 4845/4885HTT 1910/4885LMNA 4278/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.