Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | SSTR5 | P35346 | 5/20 | 0.40 |
| ▸ | FAAH | O00519 | 7/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4257512 | 0.79 | LMNA (0.48) | KMT2AMEN1FAAHMAPTALDH1A1 | |
| SCHEMBL4265584 | 0.77 | GRM2 (0.43) | KMT2AMEN1FAAH | |
| SCHEMBL4258569 | 0.76 | MMP1 (0.43) | KMT2AMEN1FAAH | |
| SCHEMBL4258527 | 0.74 | MEN1 (0.42) | KMT2AMEN1TP53MAPTKDM4E | |
| SCHEMBL4258714 | 0.74 | RIPK1 (0.48) | KMT2AMEN1MAPTKDM4EALDH1A1 | |
| SCHEMBL4257403 | 0.74 | TSHR (0.45) | KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL4271025 | 0.73 | TRPV1 (0.46) | SSTR5KDM4EALDH1A1 | |
| SCHEMBL4268039 | 0.73 | TACR2 (0.47) | KMT2AFAAHMAPTALDH1A1 | |
| SCHEMBL1085767 | 0.73 | RIPK1 (0.52) | KMT2AMEN1MAPTKDM4EALDH1A1 | |
| SCHEMBL4257388 | 0.72 | ALDH1A1 (0.48) | KMT2AMEN1SSTR5MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910381-B1 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2009-06-03 | — | — | EP | claimed |
| EP-1910381-B1 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2009-06-03 | — | — | EP | disclosed |
| EP-1910381-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007000325-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2007-01-04 | — | — | WO | disclosed |