SCHEMBL428959

SCHEMBL428959

Cc1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1

nearest known ligand 0.77

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
MLYCD O95822 2/20 0.77
NR1H2 P55055 13/20 0.61
NR1H3 Q13133 13/20 0.61
SMN1; SMN2 Q16637 3/20 0.52
RORC P51449 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL131990 0.87 NR1H2 (0.68) MLYCDNR1H2NR1H3SMN1; SMN2
SCHEMBL6820681 0.84 MLYCD (0.59) MLYCDNR1H2NR1H3RORC
Water SCHEMBL1684070 0.84 NR1H2 (0.65) MLYCDNR1H2NR1H3SMN1; SMN2
SCHEMBL18671898 0.80 NR1H2 (0.61) MLYCDNR1H2NR1H3SMN1; SMN2
SCHEMBL12562886 0.80 MLYCD (0.53) MLYCDNR1H2NR1H3SMN1; SMN2RORC
SCHEMBL14593303 0.80 NR1H2 (0.61) MLYCDNR1H2NR1H3SMN1; SMN2
SCHEMBL24901413 0.79 NR1H2 (0.61) MLYCDNR1H2NR1H3SMN1; SMN2RORC
SCHEMBL9670633 0.79 MLYCD (0.52) MLYCDNR1H2NR1H3SMN1; SMN2
SCHEMBL9621271 0.79 NR1H2 (0.60) MLYCDNR1H2NR1H3SMN1; SMN2RORC
SCHEMBL12334365 0.79 RORC (0.77) MLYCDSMN1; SMN2RORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 348 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2445939-B1 CURING COMPOSITIONS FOR FLUOROPOLYMERS 3M INNOVATIVE PROPERTIES CO (US) 2020-09-23 EP claimed
US-9437345-B2 Methods for fabricating and treating doped conjugated polymer film NATIONAL CENTRAL UNIVERSITY (TW) 2016-09-06 US claimed
US-20130105740-A1 METHODS FOR FABRICATING AND TREATING DOPED CONJUGATED POLYMER FILM NATIONAL CENTRAL UNIVERSITY (TW) 2013-05-02 US claimed
US-20120273730-A1 CONDUCTIVE POLYMER SOLUTION AND PREPARATION METHOD THEREOF NATIONAL CENTRAL UNIVERSITY (TW) 2012-11-01 US claimed
US-5288908-A Process for the preparation of fluorine containing monomers HOECHST AKTIENGESELLSCHAFT (DE) 1994-02-22 US claimed
EP-0361486-B1 FLUORINATED MONOMERS, PROCESS FOR THEIR PREPARATION AND THEIR USE HOECHST AKTIENGESELLSCHAFT (DE) 1993-03-03 EP claimed
EP-0361486-A1 Fluorinated monomers, process for their preparation and their use HOECHST AKTIENGESELLSCHAFT (DE) 1990-04-04 EP claimed
US-4455247-A FLUORINATED ALCOHOL, AND A HIGH BOILING ELETRON DONATING ABSORBENT; SANYO ELECTRIC CO., LTD. (JP) 1984-06-19 US claimed
EP-0048281-A1 COMPOSITION FOR ABSORPTION REFRIGERATOR Sanyo Electric Co., Ltd (JP) 1982-03-31 EP claimed
JP-2209849-A None JP disclosed
JP-3024027-A None JP disclosed
CN-116283898-B Method for preparing 3-methyl sulfolane 万华化学集团股份有限公司 2024-12-03 CN disclosed
US-20230322785-A1 ADENOSINE A2A AND A2B RECEPTOR DUAL ANTAGONISTS FOR IMMUNO-ONCOLOGY MERCK SHARP & DOHME LLC (US) 2023-10-12 US disclosed
US-11785845-B2 Composition FUJIFILM CORPORATION (JP) 2023-10-10 US disclosed
EP-0203462-A2 Alpha-fluoroacrylic-acid esters and their polymers HOECHST AKTIENGESELLSCHAFT (DE) 1986-12-03 EP disclosed
EP-0048281-B1 COMPOSITION FOR ABSORPTION REFRIGERATOR Sanyo Electric Co., Ltd (JP) 1985-06-19 EP disclosed
US-4455247-A FLUORINATED ALCOHOL, AND A HIGH BOILING ELETRON DONATING ABSORBENT; SANYO ELECTRIC CO., LTD. (JP) 1984-06-19 US disclosed
EP-0026289-B1 ANTIHYPERTENSIVE POLYHALOHYDROXYISOPROPYL PHENYLALKANOIC AND PHENYLALKENOIC ACIDS, AMIDES AND ESTERS, PHARMACEUTICAL COMPOSITIONS THEREFROM AND INTERMEDIATES THERETO E.I. DU PONT DE NEMOURS AND COMPANY (US) 1982-06-02 EP disclosed
EP-0048281-A1 COMPOSITION FOR ABSORPTION REFRIGERATOR Sanyo Electric Co., Ltd (JP) 1982-03-31 EP disclosed
EP-0026289-A1 Antihypertensive polyhalohydroxyisopropyl phenylalkanoic and phenylalkenoic acids, amides and esters, pharmaceutical compositions therefrom and intermediates thereto E.I. DU PONT DE NEMOURS AND COMPANY (US) 1981-04-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11785845-B2 Composition ADH1A, ADH1C, SLC19A2 MLYCD 3157/4885NR1H2 794/4885NR1H3 515/4885
US-20230322785-A1 ADENOSINE A2A AND A2B RECEPTOR DUAL ANTAGONISTS FOR IMMUNO-ONCOLOGY ADORA2A, ADORA2B, ADORA1 MLYCD 4804/4885NR1H2 1969/4885NR1H3 2388/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.