SCHEMBL432902

SCHEMBL432902

C=CCNc1ncc2nc[nH]c2n1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
INSR P06213 1/20 0.43
IGF1R P08069 1/20 0.43
FGFR1 P11362 1/20 0.43
KDR P35968 1/20 0.43
HTR2A P28223 1/20 0.36
ALDH1A1 P00352 3/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
GAA P10253 2/20 0.33
RAB9A P51151 3/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
KDM4E B2RXH2 2/20 0.33
NPC1 O15118 1/20 0.33
MAPT P10636 3/20 0.33
KMT2A Q03164 2/20 0.33
MEN1 O00255 1/20 0.33
SUMO3 P55854 1/20 0.32
SUMO2 P61956 1/20 0.32
SUMO1 P63165 1/20 0.32
HCAR3 P49019 1/20 0.32
HIF1A Q16665 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9363797 0.77 TSHR (0.48) CDK1CYP1A2
SCHEMBL2402013 0.76 CDK2 (0.50) INSRIGF1RFGFR1KDRHTR2A
SCHEMBL16873181 0.75 CYP3A4 (0.40) ALDH1A1GAARAB9AKDM4EKMT2A
SCHEMBL5934350 0.75 HTT (0.40) ALDH1A1KMT2AMEN1MAPK1LMNA
SCHEMBL30850669 0.74 CDK4 (0.35) CDK1
SCHEMBL5184898 0.73 ADORA3 (0.32) ALDH1A1GAAKDM4EHPGD
SCHEMBL1019383 0.73 IP6K1 (0.47) ALDH1A1RAB9ASMN1; SMN2KDM4EMAPT
SCHEMBL17099324 0.72 XDH (0.43) KMT2ACYP1A2CYP3A4CYP2C19
SCHEMBL8523000 0.72 INSR (0.39) INSRIGF1RFGFR1KDRHTR2A
SCHEMBL4241034 0.72

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 114 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230346812-A1 METHODS FOR TREATING SARS COV-2 INFECTIONS GILEAD SCIENCES, INC. 2023-11-02 US disclosed
US-11660307-B2 Methods for treating SARS CoV-2 infections GILEAD SCIENCES, INC. (US) 2023-05-30 US disclosed
US-20230125751-A1 METHODS AND COMPOUNDS FOR TREATING PARAMYXOVIRIDAE VIRUS INFECTIONS GILEAD SCIENCES, INC. 2023-04-27 US disclosed
US-20230027727-A1 METHODS FOR TREATING ARENAVIRIDAE AND CORONAVIRIDAE VIRUS INFECTIONS GILEAD SCIENCES, INC. 2023-01-26 US disclosed
EP-4096678-A1 METHODS FOR TREATING SARS COV-2 INFECTIONS GILEAD SCIENCES, INC. (US) 2022-12-07 EP disclosed
EP-4088718-A1 METHODS FOR TREATING CORONAVIRIDAE VIRUS INFECTIONS Gilead Sciences, Inc. (US) 2022-11-16 EP disclosed
US-20220227776-A1 PRODRUGS OF 1'-SUBSTITUTED CARBA-NUCLEOSIDE ANALOGUES FOR ANTIVIRAL TREATMENT Copycat Sciences Inc. (US) 2022-07-21 US disclosed
US-11382926-B2 Methods for treating Arenaviridae and Coronaviridae virus infections GILEAD SCIENCES, INC. (US) 2022-07-12 US disclosed
US-11344565-B2 Methods for the preparation of ribosides GILEAD SCIENCES, INC. (US) 2022-05-31 US disclosed
US-11266666-B2 Methods for treating Filoviridae virus infections GILEAD SCIENCES, INC. (US) 2022-03-08 US disclosed
US-20110038833-A1 MODIFIED FLUORINATED NUCLEOSIDE ANALOGUES PHARMASSET, INC. (US) 2011-02-17 US disclosed
US-20100234585-A1 PREPARATION OF ALKYL-SUBSTITUTED 2-DEOXY-2-FLUORO-D-RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES PHARMASSET, INC. (US) 2010-09-16 US disclosed
EP-2227482-A1 2',4'-SUBSTITUTED NUCLEOSIDES AS ANTIVIRAL AGENTS Pharmasset, Inc. (US) 2010-09-15 EP disclosed
US-20100081628-A1 NUCLEOSIDE CYCLICPHOSPHATES PHARMASSET, INC. (US) 2010-04-01 US disclosed
US-20090318380-A1 2',4'-SUBSTITUTED NUCLEOSIDES AS ANTIVIRAL AGENTS PHARMASSET, INC. (US) 2009-12-24 US disclosed
WO-2009152095-A2 NUCLEOSIDE CYCLICPHOSPHATES PHARMASSET, INC. (US) 2009-12-17 WO disclosed
WO-2009067409-A1 2',4'-SUBSTITUTED NUCLEOSIDES AS ANTIVIRAL AGENTS PHARMASSET, INC. (US) 2009-05-28 WO disclosed
US-20090036666-A1 MODIFIED FLUORINATED NUCLEOSIDE ANALOGUES PHARMASSET, INC. (US) 2009-02-05 US disclosed
US-20090004135-A1 MODIFIED FLUORINATED NUCLEOSIDE ANALOGUES PHARMASSET, INC. (US) 2009-01-01 US disclosed
US-20080070861-A1 MODIFIED FLUORINATED NUCLEOSIDE ANALOGUES PHARMASSET, INC. (US) 2008-03-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (15 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090318380-A1 2',4'-SUBSTITUTED NUCLEOSIDES AS ANTIVIRAL AGENTS HAVCR2, NUDT1, NT5C3B INSR 3117/4885IGF1R 4200/4885FGFR1 4057/4885
US-20080070861-A1 MODIFIED FLUORINATED NUCLEOSIDE ANALOGUES NSUN2, NT5C3B, METTL3 INSR 3208/4885IGF1R 4779/4885FGFR1 711/4885
US-11344565-B2 Methods for the preparation of ribosides RUVBL2, RUVBL1, EIF2AK2 INSR 1536/4885IGF1R 2483/4885FGFR1 3620/4885
US-20090036666-A1 MODIFIED FLUORINATED NUCLEOSIDE ANALOGUES NSUN2, NT5C3B, METTL3 INSR 3208/4885IGF1R 4779/4885FGFR1 711/4885
US-11382926-B2 Methods for treating Arenaviridae and Coronaviridae virus infections ACE, PNP, ACE2 INSR 3009/4885IGF1R 4390/4885FGFR1 4169/4885
US-20230125751-A1 METHODS AND COMPOUNDS FOR TREATING PARAMYXOVIRIDAE VIRUS INFECTIONS PNP, RPIA, HPRT1 INSR 3424/4885IGF1R 4488/4885FGFR1 2199/4885
US-11660307-B2 Methods for treating SARS CoV-2 infections ACE2, ACE, PNP INSR 1653/4885IGF1R 4503/4885FGFR1 3226/4885
US-20100234585-A1 PREPARATION OF ALKYL-SUBSTITUTED 2-DEOXY-2-FLUORO-D-RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES NSUN2, FBL, UMPS INSR 2866/4885IGF1R 4026/4885FGFR1 2540/4885
US-20110038833-A1 MODIFIED FLUORINATED NUCLEOSIDE ANALOGUES NSUN2, NT5C3B, METTL3 INSR 3208/4885IGF1R 4779/4885FGFR1 711/4885
US-20220227776-A1 PRODRUGS OF 1'-SUBSTITUTED CARBA-NUCLEOSIDE ANALOGUES FOR ANTIVIRAL TREATMENT ACE2, ACE, PNP INSR 2364/4885IGF1R 4658/4885FGFR1 2203/4885
US-20230346812-A1 METHODS FOR TREATING SARS COV-2 INFECTIONS ACE2, ACE, PNP INSR 1653/4885IGF1R 4503/4885FGFR1 3226/4885
US-20100081628-A1 NUCLEOSIDE CYCLICPHOSPHATES PNP, NUDT1, TYMP INSR 1770/4885IGF1R 4644/4885FGFR1 1379/4885
US-20090004135-A1 MODIFIED FLUORINATED NUCLEOSIDE ANALOGUES NSUN2, NT5C3B, METTL3 INSR 3208/4885IGF1R 4779/4885FGFR1 711/4885
US-20230027727-A1 METHODS FOR TREATING ARENAVIRIDAE AND CORONAVIRIDAE VIRUS INFECTIONS PNP, ACE, ACE2 INSR 3084/4885IGF1R 4371/4885FGFR1 4142/4885
US-11266666-B2 Methods for treating Filoviridae virus infections PNP, PRPF4, RPIA INSR 4540/4885IGF1R 4802/4885FGFR1 2662/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.