Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.40 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4329107 | 0.91 | ALDH1A1 (0.45) | CYP2A6CYP3A4MAPTLMNAKDM4E | |
| SCHEMBL4329428 | 0.88 | CYP2A6 (0.43) | CYP2A6CYP3A4MAPTLMNAKDM4E | |
| SCHEMBL4331909 | 0.88 | CYP2A6 (0.43) | CYP2A6CYP3A4MAPTLMNAKDM4E | |
| SCHEMBL4334594 | 0.88 | MAPT (0.46) | CYP2A6CYP3A4MAPTLMNAKDM4E | |
| SCHEMBL4340661 | 0.88 | CYP2A6 (0.42) | CYP2A6CYP3A4MAPTLMNAKDM4E | |
| SCHEMBL4333822 | 0.86 | ALDH1A1 (0.50) | CYP2A6CYP3A4MAPTLMNAKDM4E | |
| SCHEMBL4323303 | 0.86 | KDM4E (0.42) | CYP2A6CYP3A4MAPTLMNAKDM4E | |
| SCHEMBL4328924 | 0.86 | SLC9A1 (0.42) | CYP2A6CYP3A4MAPTLMNAMEN1 | |
| SCHEMBL4343237 | 0.86 | SIGMAR1 (0.51) | CYP2A6CYP3A4MAPTLMNAKDM4E | |
| SCHEMBL4329296 | 0.84 | G6PC1 (0.47) | MAPTLMNAKMT2AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935235-A1 | INDENOPHENANTHRENE BASED COMPOUNDS | Merck Patent GmbH (DE) | 2015-10-28 | — | — | EP | claimed |
| WO-2014094954-A1 | INDENOPHENANTHRENE BASED COMPOUNDS | MERCK PATENT GMBH (DE) | 2014-06-26 | — | — | WO | claimed |
| CN-109503454-A | A kind of preparation method of Benzazole compounds | 北京化工大学 | 2019-03-22 | — | — | CN | disclosed |
| US-20170050942-A1 | 3-CYCLOALKYLAMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE CORP (US) | 2017-02-23 | — | — | US | disclosed |
| CN-102106847-B | A kind of new liposoluble platinum class ejection preparation and its production and use | Qilu Pharmaceutical Co.,Ltd. (CN) | 2015-09-23 | — | — | CN | disclosed |
| US-20150231114-A1 | 3-CYCLOALKYLAMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | PFIZER (US) | 2015-08-20 | — | — | US | disclosed |
| CN-103351358-B | Method for preparing 5-substituted-2-thiazolidinone | UNIV BEIJING CHEMICAL | 2015-05-27 | — | — | CN | disclosed |
| CN-102344398-B | 3-cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors | INCYTE CORP | 2015-02-25 | — | — | CN | disclosed |
| US-20140155377-A1 | 3-CYCLOALKYLAMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE CORPORATION (US) | 2014-06-05 | — | — | US | disclosed |
| CN-102086171-B | Oxime ester compound and photopolymerization initiator containing same | ADEKA CORP | 2014-05-14 | — | — | CN | disclosed |
| US-8697870-B2 | 3-cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors | INCYTE CORPORATION (US) | 2014-04-15 | — | — | US | disclosed |
| EP-1696919-A2 | 3-CYCLOALKYLAMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | Incyte Corporation (US) | 2006-09-06 | — | — | EP | disclosed |
| US-20050192302-A1 | 3-Cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors | PFIZER INC. | 2005-09-01 | — | — | US | disclosed |
| WO-2005060665-A2 | 3-CYCLOALKYLAMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE CORPORATION (US) | 2005-07-07 | — | — | WO | disclosed |
| US-20050069555-A1 | Thiosemicarbazones as anti-virals and immunopotentiators | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2005-03-31 | — | — | US | disclosed |
| CN-1058283-C | Sulfopolymer/vanadium oxide antistatic compositions | MINNESOTA MINING & MFG (US) | 2000-11-08 | — | — | CN | disclosed |
| EP-0904272-A1 | DIHYDROBENZOFURAN AND RELATED COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | THE PROCTER & GAMBLE COMPANY (US) | 1999-03-31 | — | — | EP | disclosed |
| US-5686471-A | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents | THE PROCTER & GAMBLE COMPANY (US) | 1997-11-11 | — | — | US | disclosed |
| WO-1997028155-A1 | DIHYDROBENZOFURAN AND RELATED COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | THE PROCTER & GAMBLE COMPANY (US) | 1997-08-07 | — | — | WO | disclosed |
| CN-1079493-A | Sulfosalicylic polymer/vanadium oxide antistatic composition | MINNESOTA MINING & MFG (US) | 1993-12-15 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140155377-A1 | 3-CYCLOALKYLAMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | CCR2, CCR5, CXCR3 | CYP2A6 2812/4885CYP3A4 2607/4885MAPT 4769/4885 |
| US-20050192302-A1 | 3-Cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors | CCR2, CCR5, CXCR3 | CYP2A6 2818/4885CYP3A4 2581/4885MAPT 4779/4885 |
| US-20050069555-A1 | Thiosemicarbazones as anti-virals and immunopotentiators | MAVS, IRF3, HAVCR2 | CYP2A6 1753/4885CYP3A4 916/4885MAPT 3876/4885 |
| US-20150231114-A1 | 3-CYCLOALKYLAMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | CCR2, CCR5, CXCR3 | CYP2A6 2827/4885CYP3A4 2490/4885MAPT 4806/4885 |
| US-20170050942-A1 | 3-CYCLOALKYLAMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | CCR2, CCR5, CXCR3 | CYP2A6 2818/4885CYP3A4 2581/4885MAPT 4779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.