SCHEMBL43429

SCHEMBL43429

[N-]=[N+]=CC(=O)OCc1ccc(F)c(F)c1F

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
ALKBH1 Q13686 1/20 0.35
CA2 P00918 1/20 0.35
RIPK1 Q13546 1/20 0.34
CES2 O00748 1/20 0.33
CES1 P23141 1/20 0.33
P2RX7 Q99572 6/20 0.32
HCAR2 Q8TDS4 2/20 0.32
MMP2 P08253 4/20 0.32
MMP12 P39900 4/20 0.32
MMP1 P03956 3/20 0.32
MMP9 P14780 3/20 0.32
ALDH1A1 P00352 2/20 0.30
NPC1 O15118 1/20 0.30
RAB9A P51151 1/20 0.30
ATM Q13315 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30
KDM4E B2RXH2 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL43822 0.78 MMP2 (0.43) CYP1A2CYP2C9CYP2C19HCAR2MMP2
SCHEMBL7125691 0.75 CYP1A2 (0.33) CYP1A2CYP2C9CYP2C19CA2HCAR2
SCHEMBL43498 0.74 MMP1 (0.36) CYP1A2CYP2C9CYP2C19MMP2MMP12
SCHEMBL13034113 0.74 ALDH1A1 (0.44) ALKBH1CA2RIPK1CES2CES1
SCHEMBL13811663 0.72 RIPK1 (0.41) ALKBH1CA2RIPK1CES2CES1
SCHEMBL5318170 0.70 NFKB1 (0.45) CA2NPC1RAB9AATMKDM4E
SCHEMBL43967 0.69 HCAR2 (0.59) CYP1A2CYP2C9CYP2C19HCAR2ALDH1A1
SCHEMBL43499 0.69 CES2 (0.33) CYP1A2CYP2C9CYP2C19CES2CES1
SCHEMBL17552782 0.67 RIPK1 (0.56) ALKBH1RIPK1P2RX7ALDH1A1NPC1
SCHEMBL4606745 0.66 F13A1 (0.46) ALKBH1RIPK1CES2CES1HCAR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011157444-A1 FUNCTIONALIZED MATERIALS BY CATALYZED CARBENE COPOLYMERIZATION STICHTING DUTCH POLYMER INSTITUTE (NL) 2011-12-22 WO disclosed