SCHEMBL434300

SCHEMBL434300

Cc1ccc2[nH]c(=O)ccc2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 2/20 1.00
CA9 Q16790 2/20 1.00
F11 P03951 1/20 0.60
MAPT P10636 2/20 0.55
DAO P14920 2/20 0.55
CA1 P00915 1/20 0.52
CA3 P07451 1/20 0.52
CA4 P22748 1/20 0.52
CA6 P23280 1/20 0.52
CA5A P35218 1/20 0.52
CA7 P43166 1/20 0.52
CA13 Q8N1Q1 1/20 0.52
CA14 Q9ULX7 1/20 0.52
CA5B Q9Y2D0 1/20 0.52
PIN1 Q13526 1/20 0.50
DDO Q99489 1/20 0.50
POLB P06746 1/20 0.49
PDGFRB P09619 1/20 0.49
PDGFRA P16234 1/20 0.49
LMNA P02545 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL436560 0.85 CA12 (0.74) CA12CA9F11MAPTDAO
SCHEMBL16573987 0.85 CA12 (0.73) CA12CA9F11MAPTDAO
SCHEMBL13680545 0.81 CA12 (0.67) CA12CA9F11MAPTCA1
SCHEMBL6031111 0.77 CA12 (0.62) CA12CA9F11MAPTCA1
SCHEMBL2947571 0.77 CA12 (0.62) CA12CA9F11MAPTDAO
SCHEMBL15345000 0.76 CA12 (0.59) CA12CA9F11MAPTCA1
SCHEMBL607156 0.75 CA12 (0.60) CA12CA9F11DAOCA1
SCHEMBL11461336 0.75 CA12 (0.60) CA12CA9MAPTDAOPIN1
SCHEMBL3368797 0.75 CA12 (0.60) CA12CA9F11CA1CA3
SCHEMBL14279696 0.75 CA12 (0.60) CA12CA9F11MAPTCA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 304 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111850631-A High-gloss decorative rhodium-plated layer electroplating solution 金川集团股份有限公司 2020-10-30 CN claimed
EP-3542801-A1 PURIN DERIVATIVES FOR USE IN THE TREATMENT OF FAP-RELATED DISEASES Boehringer Ingelheim International GmbH (DE) 2019-09-25 EP claimed
US-20160136180-A1 PURIN DERIVATIVES FOR USE IN THE TREATMENT OF FAB-RELATED DISEASES BOEHRINGER INGELHEIM INT (DE) 2016-05-19 US claimed
US-20110112069-A1 PURIN DERIVATIVES FOR USE IN THE TREATMENT OF FAB-RELATED DISEASES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-05-12 US claimed
EP-2190434-A2 PURIN DERIVATIVES FOR USE IN THE TREATMENT OF FAB-RELATED DISEASES Boehringer Ingelheim International GmbH (DE) 2010-06-02 EP claimed
WO-2009024542-A2 PURIN DERIVATIVES FOR USE IN THE TREATMENT OF FAB-RELATED DISEASES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2009-02-26 WO claimed
US-20260068882-A1 ARTHROPOD CONTROLLING COMPOSITION FIRMENICH & CIE (CH) 2026-03-12 US disclosed
US-20260015337-A1 COMPOUNDS FOR TREATMENT A CORONAVIRUS INFECTION TRAWSFYNYDD THERAPEUTICS INC (US) 2026-01-15 US disclosed
CN-113905612-B Arthropod control composition 弗门尼舍有限公司 2025-04-08 CN disclosed
US-20240374583-A1 USE OF MORPHINAN DERIVATIVES FOR TREATMENT OF OPIOID DELTA RECEPTOR AGONIST-RELATED DISEASE NIPPON CHEMIPHAR CO., LTD (JP) 2024-11-14 US disclosed
US-12109209-B2 Use of morphinan derivatives for treatment of opioid delta receptor agonist-related disease NIPPON CHEMIPHAR CO., LTD. (JP) 2024-10-08 US disclosed
US-20240327354-A1 GRAM-NEGATIVE BACTERIA EFFLUX PUMP INHIBITORS INSTITUT PASTEUR DE LILLE (FR) 2024-10-03 US disclosed
US-12102631-B2 Quinolylnitrones for the treatment and prevention of a cerebral stroke or ischaemia CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) (ES) 2024-10-01 US disclosed
US-5217977-A Lipoxygenase inhibitor for treating diseases medicated by leukotrienes IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-06-08 US disclosed
US-5196419-A Lipoxygenase enzyme inhibitor IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-03-23 US disclosed
US-5134148-A Heterocycles for use as inhibitors of leukotrienes IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-07-28 US disclosed
US-5112837-A Inhibitors of thymidylate synthetase enzyme IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-05-12 US disclosed
EP-0385662-A2 Heterocycles with inhibitory activity of 5-lipoxygenase ZENECA LIMITED (GB) 1990-09-05 EP disclosed
EP-0385663-A2 Heterocyclic cycloalkanes as inhibitors of 5-lipoxygenase ZENECA LIMITED (GB) 1990-09-05 EP disclosed
EP-0385679-A2 Heterocyclic cyclic ethers with inhibitory activity on 5-lipoxygenase ZENECA LIMITED (GB) 1990-09-05 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12102631-B2 Quinolylnitrones for the treatment and prevention of a cerebral stroke or ischaemia NLN, TXN2, TXN CA12 1382/4885CA9 1766/4885F11 786/4885
US-20260068882-A1 ARTHROPOD CONTROLLING COMPOSITION CNOT9, MSL1, MT-CO2 CA12 1643/4885CA9 115/4885F11 1213/4885
US-20240327354-A1 GRAM-NEGATIVE BACTERIA EFFLUX PUMP INHIBITORS ABCB11, ABCB1, ATP4B CA12 4622/4885CA9 2996/4885F11 3921/4885
US-20260015337-A1 COMPOUNDS FOR TREATMENT A CORONAVIRUS INFECTION ACE2, ACE, TMPRSS2 CA12 1648/4885CA9 1118/4885F11 1446/4885
US-20240374583-A1 USE OF MORPHINAN DERIVATIVES FOR TREATMENT OF OPIOID DELTA RECEPTOR AGONIST-RELATED DISEASE OPRD1, OPRM1, OPRK1 CA12 4504/4885CA9 4836/4885F11 3636/4885
US-12109209-B2 Use of morphinan derivatives for treatment of opioid delta receptor agonist-related disease OPRD1, OPRM1, OPRK1 CA12 4504/4885CA9 4836/4885F11 3636/4885
US-20160136180-A1 PURIN DERIVATIVES FOR USE IN THE TREATMENT OF FAB-RELATED DISEASES PNP, ENTPD5, NUDT14 CA12 4805/4885CA9 4823/4885F11 2981/4885
US-20110112069-A1 PURIN DERIVATIVES FOR USE IN THE TREATMENT OF FAB-RELATED DISEASES PNP, PURB, NUDT14 CA12 4773/4885CA9 4787/4885F11 2972/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.