SCHEMBL435160

SCHEMBL435160

CC(C)[Si](C=Cc1ccccc1O)(O[Si](C=Cc1ccccc1O)(C(C)C)C(C)C)C(C)C

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 1/20 0.45
ABCB1 P08183 1/20 0.45
BCR P11274 1/20 0.45
MAPT P10636 3/20 0.43
LMNA P02545 2/20 0.43
TRPA1 O75762 1/20 0.43
NFKB1 P19838 2/20 0.42
CDK4 P11802 1/20 0.42
CCND1 P24385 1/20 0.42
JUN P05412 1/20 0.42
NFE2L2 Q16236 1/20 0.42
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA4 P22748 1/20 0.41
MAPK1 P28482 2/20 0.40
NPSR1 Q6W5P4 2/20 0.40
NPC1 O15118 2/20 0.40
KDM4E B2RXH2 1/20 0.40
RAB9A P51151 1/20 0.40
ATM Q13315 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL435159 1.00 ABL1 (0.45) ABL1ABCB1BCRMAPTLMNA
SCHEMBL2351168 0.79 MAPT (0.46) ABL1ABCB1BCRMAPTLMNA
SCHEMBL7030353 0.77 MAPT (0.44) ABL1ABCB1BCRMAPTLMNA
SCHEMBL7028957 0.77 MAPT (0.44) ABL1ABCB1BCRMAPTLMNA
SCHEMBL7030351 0.77 MAPT (0.44) ABL1ABCB1BCRMAPTLMNA
SCHEMBL7028954 0.77 MAPT (0.44) ABL1ABCB1BCRMAPTLMNA
SCHEMBL433096 0.77 MAPT (0.47) ABL1ABCB1BCRMAPTLMNA
SCHEMBL433097 0.77 MAPT (0.47) ABL1ABCB1BCRMAPTLMNA
SCHEMBL5345374 0.74 TRPA1 (0.52) ABL1ABCB1BCRMAPTLMNA
SCHEMBL5345372 0.74 TRPA1 (0.52) ABL1ABCB1BCRMAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 94 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3645548-B1 METHODS FOR PREPARING BILE ACIDS MEDYTOX INC (KR) 2023-11-29 EP disclosed
US-11324827-B2 Multifunctionalized polyethylene glycol derivative and preparation method therefor XIAMEN SINOPEG BIOTECH CO., LTD. (CN) 2022-05-10 US disclosed
US-20220009957-A1 Methods for Preparing Bile Acids MEDYTOX INC. (KR) 2022-01-13 US disclosed
US-11161872-B2 Methods for preparing bile acids MEDYTOX INC. (KR) 2021-11-02 US disclosed
US-20200369712-A1 METHODS FOR PREPARING BILE ACIDS WUXI APPTEC (SHANGHAI) CO., LTD. (CN) 2020-11-26 US disclosed
EP-3268353-B1 PYRAZOLYL DERIVATIVES AS PEST CONTROL AGENTS BAYER ANIMAL HEALTH GMBH (DE) 2020-09-09 EP disclosed
EP-3640236-A1 A METHOD OF PRODUCING INGENOL-3-ANGELATE LEO LABORATORIES LIMITED (IE) 2020-04-22 EP disclosed
EP-2595948-B1 A METHOD OF PRODUCING INGENOL-3-ANGELATE LEO LABORATORIES LTD (IE) 2019-09-04 EP disclosed
EP-1981544-B1 BIODEGRADABLE AND THERMOSENSITIVE POLY(ORGANOPHOSPHAZENE) HYDROGEL, PREPARATION METHOD THEREOF AND USE THEREOF KIST KOREA INSTITUTE OF SCIENCE AND TECH (KR) 2019-06-19 EP disclosed
US-10299478-B2 Pyrazolyltriazolylpyridines as pesticides BAYER ANIMAL HEALTH GMBH (DE) 2019-05-28 US disclosed
US-20090022683-A1 Biodegradable and Thermosensitive Poly(Organophosphazene) Hydrogel, Preparation Method Thereof and Use Thereof KIST (KR) 2009-01-22 US disclosed
WO-2008153278-A1 PHOSPHAZENE HYDROGELS WITH CHEMICAL CORSS -LINK, PREPARATION METHOD THEREOF AND USE THEREOF KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2008-12-18 WO disclosed
WO-2008153277-A1 POLY(ORGANOPHOSPHAZENE) HYDROGELS FOR DRUG DELIVERY, PREPARATION METHOD THEREOF AND USE THEREOF KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2008-12-18 WO disclosed
EP-2001513-A1 THERMOSENSITIVE POLYPHOSPHAZENE-BIOACTIVE MOLECULE CONJUGATES, PREPARATION METHOD THEROF AND USE THEREOF Korea Institute of Science and Technology (KR) 2008-12-17 EP disclosed
EP-1981544-A2 BIODEGRADABLE AND THERMOSENSITIVE POLY(ORGANOPHOSPHAZENE) HYDROGEL, PREPARATION METHOD THEREOF AND USE THEREOF KIST Korea Institute of Science and Technology (KR) 2008-10-22 EP disclosed
EP-1896480-A1 CRIPOWELLINS AND SYNTHETIC DERIVATIVES THEREOF USED AS MEDICAMENTS Bayer CropScience Aktiengesellschaft (DE) 2008-03-12 EP disclosed
WO-2008019784-A2 AVERMECTIN DERIVATIVES BAYER CROPSCIENCE AG (DE) 2008-02-21 WO disclosed
WO-2007114549-A1 THERMOSENSITIVE POLYPHOSPHAZENE-BIOACTIVE MOLECULE CONJUGATES, PREPARATION METHOD THEROF AND USE THEREOF KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2007-10-11 WO disclosed
WO-2007083875-A2 BIODEGRADABLE AND THERMOSENSITIVE POLY(ORGANOPHOSPHAZENE) HYDROGEL, PREPARATION METHOD THEREOF AND USE THEREOF KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2007-07-26 WO disclosed
WO-2006136309-A1 CRIPOWELLINS AND SYNTHETIC DERIVATIVES THEREOF USED AS MEDICAMENTS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2006-12-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10299478-B2 Pyrazolyltriazolylpyridines as pesticides PRDX4, PRDX1, ATL3 ABL1 3641/4885ABCB1 3665/4885BCR 4566/4885
US-20090022683-A1 Biodegradable and Thermosensitive Poly(Organophosphazene) Hydrogel, Preparation Method Thereof and Use Thereof PHOSPHO1, PGLS, LIPE ABL1 2268/4885ABCB1 387/4885BCR 877/4885
US-20220009957-A1 Methods for Preparing Bile Acids DHCR7, CYP46A1, CYP27A1 ABL1 4116/4885ABCB1 754/4885BCR 4442/4885
US-20200369712-A1 METHODS FOR PREPARING BILE ACIDS DHCR7, CYP46A1, CYP27A1 ABL1 4116/4885ABCB1 754/4885BCR 4442/4885
US-11161872-B2 Methods for preparing bile acids DHCR7, CYP46A1, CYP27A1 ABL1 4116/4885ABCB1 754/4885BCR 4442/4885
US-11324827-B2 Multifunctionalized polyethylene glycol derivative and preparation method therefor HDGF, F11, F12 ABL1 3984/4885ABCB1 4404/4885BCR 1671/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.