Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 8/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL721718 | 0.79 | SMN1; SMN2 (0.44) | PRKDCNPY5RALDH1A1NPC1POLB | |
| Hydrochloric Acid SCHEMBL9937226 | 0.77 | SMN1; SMN2 (0.43) | PRKDCNPY5RALDH1A1NPC1POLB | |
| SCHEMBL3899588 | 0.67 | USP2 (0.42) | NPY5RALDH1A1TSHRPOLBMAPK1 | |
| SCHEMBL3511781 | 0.63 | PRKDC (0.44) | PRKDCALDH1A1NPC1POLBMAPT | |
| SCHEMBL3961892 | 0.62 | TAAR1 (0.46) | PRKDCALDH1A1TSHRMAPK1SMN1; SMN2 | |
| SCHEMBL27736349 | 0.62 | ALDH1A1 (0.42) | ALDH1A1TSHRMAOA | |
| SCHEMBL4740418 | 0.61 | KDM4E (0.38) | PRKDCALDH1A1TSHRNPC1POLB | |
| SCHEMBL30729286 | 0.61 | NPC1 (0.57) | PRKDCALDH1A1TSHRNPC1POLB | |
| SCHEMBL1889513 | 0.61 | LMNA (0.46) | ALDH1A1TSHRNPC1POLBMAPT | |
| SCHEMBL9706402 | 0.61 | ALDH1A1 (0.42) | NPY5RALDH1A1TSHRPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090042895-A1 | Antidepressant Piperidine Derivatives of Heterocycle-Fused Benzodioxans | WYETH (US) | 2009-02-12 | — | — | US | disclosed |
| US-7479500-B2 | Antidepressant piperidine derivatives of heterocyclefused benzodioxans | WYETH (US) | 2009-01-20 | — | — | US | disclosed |
| US-20050228009-A1 | Antidepressant piperidine derivatives of heterocyclefused benzodioxans | WYETH (US) | 2005-10-13 | — | — | US | disclosed |
| US-6939877-B2 | Antidepressant piperidine derivatives of heterocycle-fused benzodioxans | WYETH (US) | 2005-09-06 | — | — | US | disclosed |
| EP-1537120-A1 | ANTIDEPRESSANT PIPERIDINE DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS | Wyeth, A Corporation of the State of Delaware (US) | 2005-06-08 | — | — | EP | disclosed |
| US-20040147523-A1 | Antidepressant piperidine derivatives of heterocycle-fused benzodioxans | WYETH | 2004-07-29 | — | — | US | disclosed |
| WO-2004024733-A1 | ANTIDEPRESSANT PIPERIDINE DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS | WYETH (US) | 2004-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050228009-A1 | Antidepressant piperidine derivatives of heterocyclefused benzodioxans | HTR5A, OPRD1, DRD2 | PRKDC 3459/4885NPY5R 57/4885ALDH1A1 232/4885 |
| US-20040147523-A1 | Antidepressant piperidine derivatives of heterocycle-fused benzodioxans | HTR5A, OPRD1, CRH | PRKDC 3756/4885NPY5R 47/4885ALDH1A1 363/4885 |
| US-20090042895-A1 | Antidepressant Piperidine Derivatives of Heterocycle-Fused Benzodioxans | HTR5A, OPRD1, CRH | PRKDC 3497/4885NPY5R 47/4885ALDH1A1 394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.