Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TXNRD1 | Q16881 | 8/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4359579 | 0.79 | HTT (0.51) | ALDH1A1HTTMERTKMEN1KMT2A | |
| SCHEMBL4361885 | 0.76 | NR4A1 (0.43) | LMNASMN1; SMN2IKBKB | |
| SCHEMBL28281419 | 0.74 | PGR (0.44) | ALDH1A1HTTKDM4ECYP3A4LMNA | |
| SCHEMBL6972835 | 0.74 | SDHB (0.40) | ALDH1A1HTTKDM4ECYP3A4LMNA | |
| SCHEMBL4936641 | 0.72 | PIN1 (0.46) | ALDH1A1HTTMERTKMEN1KMT2A | |
| SCHEMBL10845927 | 0.72 | TLR4 (0.54) | ALDH1A1HTTTXNRD1MEN1KMT2A | |
| SCHEMBL4543292 | 0.71 | ALDH1A1 (0.64) | ALDH1A1HTTMEN1KMT2AKDM4E | |
| SCHEMBL8669831 | 0.70 | ALDH1A1 (0.53) | ALDH1A1MEN1KMT2AKDM4EPOLB | |
| SCHEMBL27836920 | 0.69 | KMT2A (0.41) | ALDH1A1HTTTXNRD1MEN1KMT2A | |
| SCHEMBL4365660 | 0.68 | KDR (0.44) | ALDH1A1HTTMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7531553-B2 | Heterocyclic compounds and methods of use | AMGEN INC. (US) | 2009-05-12 | — | — | US | disclosed |
| US-7521579-B2 | Process for the preparation of alpha hydroxycarboxylic acid amides | SYNGENTA CROP PROTECTION, INC. (US) | 2009-04-21 | — | — | US | disclosed |
| EP-1444195-B1 | PROCESS FOR THE PREPARATION OF ALPHA-HYDROXYCARBOXYLIC ACID AMIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2005-08-10 | — | — | EP | disclosed |
| EP-1526128-A2 | Process the preparation of alpha-hydroxycarboxylic acid amides | Syngenta Participations AG (CH) | 2005-04-27 | — | — | EP | disclosed |
| US-20050014950-A1 | Process for the preparation of alpha hydroxycarboxylic acid amides | SYNGENTA CROP PROTECTION, INC. | 2005-01-20 | — | — | US | disclosed |
| US-20040209892-A1 | Heterocyclic compounds and methods of use | U.S. PATENT OPERATIONS | 2004-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014950-A1 | Process for the preparation of alpha hydroxycarboxylic acid amides | HCAR1, HCAR3, HCAR2 | ALDH1A1 103/4885HTT 541/4885TXNRD1 3439/4885 |
| US-20040209892-A1 | Heterocyclic compounds and methods of use | VHL, NQO1, HPGDS | ALDH1A1 255/4885HTT 1040/4885TXNRD1 1384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.