Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | CCR8 | P51685 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.32 |
| ▸ | CD44 | P16070 | 1/20 | 0.30 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL437482 | 0.91 | CYP3A4 (0.35) | POLBKDM4ECYP3A4MAPTMEN1 | |
| SCHEMBL436403 | 0.77 | POLB (0.38) | POLBKDM4EMAPTMEN1LMNA | |
| SCHEMBL436747 | 0.75 | CYP3A4 (0.32) | POLBKDM4ECYP3A4MAPTMEN1 | |
| SCHEMBL442075 | 0.74 | HAVCR2 (0.46) | POLBKDM4EMAPTMEN1LMNA | |
| SCHEMBL437847 | 0.74 | CCR1 (0.42) | POLBKDM4ECYP3A4MAPTLMNA | |
| SCHEMBL437555 | 0.74 | HAVCR2 (0.38) | CYP3A4HAVCR2DYRK1A | |
| SCHEMBL438132 | 0.72 | GABRP (0.49) | POLBKDM4EMAPTMEN1LMNA | |
| SCHEMBL442158 | 0.71 | HAVCR2 (0.54) | KDM4EMAPTMEN1LMNAKMT2A | |
| SCHEMBL439646 | 0.69 | HAVCR2 (0.32) | MAPK1HAVCR2DYRK1A | |
| SCHEMBL22681143 | 0.69 | CCR1 (0.54) | MEN1KMT2ACCR1CCR5CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065166-A1 | Bone Modulators And Methods Therewith | ESPINA VIRGINIA (US) | 2012-03-15 | — | — | US | disclosed |