Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 13/20 | 0.48 |
| ▸ | TMPRSS6 | Q8IU80 | 9/20 | 0.48 |
| ▸ | ST14 | Q9Y5Y6 | 4/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 2/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | HPN | P05981 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1797575 | 0.92 | MMP2 (0.43) | F2TMPRSS6ST14PRSS1PRSS2 | |
| SCHEMBL4372182 | 0.90 | F10 (0.51) | F2TMPRSS6ST14F10PLG | |
| SCHEMBL1802359 | 0.84 | MMP2 (0.43) | F2TMPRSS6ST14MMP2MMP9 | |
| SCHEMBL1799334 | 0.80 | ADAM17 (0.50) | MMP2MMP9 | |
| SCHEMBL14470899 | 0.80 | ADAM17 (0.50) | MMP2MMP9 | |
| SCHEMBL1800798 | 0.77 | MMP1 (0.48) | MMP2MMP9 | |
| SCHEMBL1800796 | 0.77 | MMP1 (0.48) | MMP2MMP9 | |
| SCHEMBL1798953 | 0.75 | ADAMTS7 (0.45) | TMPRSS6ST14MMP2MMP9F10 | |
| SCHEMBL1798952 | 0.75 | ADAMTS7 (0.45) | TMPRSS6ST14MMP2MMP9F10 | |
| SCHEMBL4542969 | 0.74 | MMP13 (0.41) | MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | claimed |
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | disclosed |