Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 4/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.37 |
| ▸ | PLD2 | O14939 | 1/20 | 0.36 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551165 | 0.91 | SIGMAR1 (0.40) | MCHR1SIGMAR1KMT2ADRD4DYRK1A | |
| SCHEMBL4550682 | 0.90 | GSK3B (0.39) | DYRK1AGSK3B | |
| SCHEMBL4396992 | 0.88 | KMT2A (0.41) | MCHR1SIGMAR1KMT2ADRD4DYRK1A | |
| SCHEMBL914281 | 0.88 | DRD4 (0.41) | PLD2PLD1KMT2ADRD4DYRK1A | |
| SCHEMBL6966091 | 0.88 | DRD4 (0.41) | PLD2PLD1KMT2ADRD4DYRK1A | |
| SCHEMBL4411339 | 0.83 | HTR7 (0.38) | KMT2ADYRK1A | |
| SCHEMBL4541737 | 0.82 | SLC2A1 (0.39) | MCHR1SIGMAR1KMT2ADRD4DYRK1A | |
| SCHEMBL4401911 | 0.81 | HTR1A (0.38) | — | |
| SCHEMBL4403763 | 0.81 | TLR9 (0.42) | DYRK1AGSK3B | |
| SCHEMBL4396457 | 0.80 | HRH3 (0.42) | HRH3KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720859-B1 | CHEMOKINE RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2009-12-23 | — | — | EP | claimed |