Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 2/20 | 0.43 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | HTR2C | P28335 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | QPCT | Q16769 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4423636 | 0.90 | ALDH1A1 (0.47) | MGLLHTR2AHTR2CSLC6A4MEN1 | |
| SCHEMBL4423695 | 0.89 | HTR2A (0.41) | MGLLHTR2AHTR2CSLC6A4MEN1 | |
| SCHEMBL4429632 | 0.88 | ALDH1A1 (0.43) | HTR2AHTR2CSLC6A4PLA2G2AALDH1A1 | |
| SCHEMBL4423191 | 0.88 | NCEH1 (0.41) | MGLLHTR2AHTR2CSLC6A4TP53 | |
| SCHEMBL4417093 | 0.87 | MAPT (0.43) | MGLLHTR2AHTR2CSLC6A4ALDH1A1 | |
| SCHEMBL4418725 | 0.87 | HTR2A (0.46) | HTR2AHTR2CSLC6A4 | |
| SCHEMBL3923363 | 0.86 | HTR2A (0.51) | CFTRHTR2AHTR2CSLC6A4MEN1 | |
| SCHEMBL4426602 | 0.86 | PLA2G2A (0.42) | MGLLPLA2G2AALDH1A1 | |
| SCHEMBL4422341 | 0.86 | NCEH1 (0.43) | MGLLHTR2AHTR2CSLC6A4ALDH1A1 | |
| SCHEMBL4425161 | 0.85 | RAB9A (0.43) | HTR2AHTR2CSLC6A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583742-B1 | CB 1 RECEPTOUR INVERSE AGONISTS | HOFFMANN LA ROCHE (CH) | 2009-12-02 | — | — | EP | claimed |