Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 4/20 | 0.42 |
| ▸ | HTR2C | P28335 | 4/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 2/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4423636 | 0.90 | ALDH1A1 (0.47) | ALDH1A1HTR2AHTR2CSLC6A4PLA2G2A | |
| SCHEMBL4419939 | 0.89 | HTR2A (0.42) | ALDH1A1HSD17B10HTR2AHTR2CSLC6A4 | |
| SCHEMBL4417423 | 0.88 | MGLL (0.43) | ALDH1A1HTR2AHTR2CSLC6A4PLA2G2A | |
| SCHEMBL4426602 | 0.86 | PLA2G2A (0.42) | ALDH1A1HSD17B10PLA2G2A | |
| SCHEMBL3928022 | 0.86 | HTR2A (0.56) | ALDH1A1HTR2AHTR2CSLC6A4L3MBTL1 | |
| SCHEMBL4423695 | 0.86 | HTR2A (0.41) | ALDH1A1HSD17B10HTR2AHTR2CSLC6A4 | |
| SCHEMBL4422341 | 0.84 | NCEH1 (0.43) | ALDH1A1HSD17B10HTR2AHTR2CSLC6A4 | |
| SCHEMBL4423191 | 0.84 | NCEH1 (0.41) | ALDH1A1HSD17B10HTR2AHTR2CSLC6A4 | |
| SCHEMBL4418725 | 0.84 | HTR2A (0.46) | HTR2AHTR2CSLC6A4FAAH | |
| SCHEMBL4417093 | 0.84 | MAPT (0.43) | ALDH1A1HSD17B10HTR2AHTR2CSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583742-B1 | CB 1 RECEPTOUR INVERSE AGONISTS | HOFFMANN LA ROCHE (CH) | 2009-12-02 | — | — | EP | claimed |