Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.38 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | SNCA | P37840 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL304686 | 0.98 | CA1 (0.38) | CA1CA2CA12CA7CA14 | |
| SCHEMBL304685 | 0.98 | CA1 (0.38) | CA1CA2CA12CA7CA14 | |
| SCHEMBL560834 | 0.97 | CA1 (0.38) | CA1CA2CA12CA7CA14 | |
| SCHEMBL3433055 | 0.77 | ALDH1A1 (0.39) | CA1CA2CA12CA7CA14 | |
| SCHEMBL6537392 | 0.77 | MAPT (0.36) | ARALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL4296863 | 0.76 | ALDH1A1 (0.42) | SNCAALDH1A1HSD17B10TDP1KDM4E | |
| SCHEMBL4296989 | 0.75 | ALDH1A1 (0.42) | SNCAALDH1A1HSD17B10TDP1KDM4E | |
| SCHEMBL24725924 | 0.74 | MRGPRX2 (0.40) | AR | |
| SCHEMBL11326119 | 0.73 | AR (0.39) | CA1CA2CA12CA7AR | |
| SCHEMBL11516736 | 0.73 | ALDH1A1 (0.39) | CA1CA2CA12ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7608244-B2 | Hydrophilic light absorbing compositions for determination of physiological function in critically ill patients | MALLINCKRODT INC. (US) | 2009-10-27 | — | — | US | disclosed |
| US-20090263327-A1 | MINIMALLY INVASIVE PHYSIOLOGICAL FUNCTION MONITORING AGENTS | MALLINCKRODT INC. (US) | 2009-10-22 | — | — | US | disclosed |
| US-7556797-B2 | Minimally invasive physiological function monitoring agents | MALLINCKRODT INC. (US) | 2009-07-07 | — | — | US | disclosed |
| US-7468177-B2 | Hydrophilic light absorbing compositions for determination of physiological function in critically ill patients | MALLINCKRODT INC. (US) | 2008-12-23 | — | — | US | disclosed |
| US-7438894-B2 | Dyes for organ function monitoring | MALLINCKRODT, INC. (US) | 2008-10-21 | — | — | US | disclosed |
| US-20080056989-A1 | Novel Dyes for Organ Function Monitoring | MALLINCKRODT, INC. (US) | 2008-03-06 | — | — | US | disclosed |
| US-20070269373-A1 | HYDROPHILIC LIGHT ABSORBING COMPOSITIONS FOR DETERMINATION OF PHYSIOLOGICAL FUNCTION IN CRITICALLY ILL PATIENTS | MALLINCKRODT, INC. (US) | 2007-11-22 | — | — | US | disclosed |
| US-20070269368-A1 | HYDROPHILIC LIGHT ABSORBING COMPOSITIONS FOR DETERMINATION OF PHYSIOLOGICAL FUNCTION IN CRITICALLY ILL PATIENTS | MALLINCKRODT, INC. (US) | 2007-11-22 | — | — | US | disclosed |
| US-7297325-B2 | Hydrophilic light absorbing compositions for determination of physiological function | MALLINCKRODT INC. (US) | 2007-11-20 | — | — | US | disclosed |
| US-20070140962-A1 | Light Sensitive Compounds for Instant Determination of Organ Function | MALLINCKRODT INC. (US) | 2007-06-21 | — | — | US | disclosed |
| EP-1326649-A1 | TISSUE-SPECIFIC EXOGENOUS OPTICAL AGENTS | MALLINCKRODT INC. (US) | 2003-07-16 | — | — | EP | disclosed |
| EP-1326650-A2 | HYDROPHILIC LIGHT ABSORBING COMPOSITIONS FOR DETERMINATION OF PHYSIOLOGICAL FUNCTION IN CRITICALLY ILL PATIENTS | Mallinckrodt Inc. (US) | 2003-07-16 | — | — | EP | disclosed |
| EP-1326648-A1 | NOVEL DYES FOR ORGAN FUNCTION MONITORING | Mallinckrodt Inc. (US) | 2003-07-16 | — | — | EP | disclosed |
| EP-1326647-A1 | LIGHT SENSITIVE COMPOUNDS FOR INSTANT DETERMINATION OF ORGAN FUNCTION | Mallinckrodt Inc. (US) | 2003-07-16 | — | — | EP | disclosed |
| EP-1326602-A1 | INDOLE COMPOUNDS AS MINIMALLY PHYSIOLOGIAL FUNCTION MONITIORING AGENTS | MALLINCKRODT INC. (US) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002032285-A2 | HYDROPHILIC LIGHT ABSORBING COMPOSITIONS FOR DETERMINATION OF PHYSIOLOGICAL FUNCTION IN CRITICALLY ILL PATIENTS | MALLINCKRODT INC. (US) | 2002-04-25 | — | — | WO | disclosed |
| WO-2002032465-A1 | TISSUE-SPECIFIC EXOGENOUS OPTICAL AGENTS | MALLINCKRODT INC. (US) | 2002-04-25 | — | — | WO | disclosed |
| WO-2002032421-A1 | INDOLE COMPOUNDS AS MINIMALLY PHYSIOLOGIAL FUNCTION MONITIORING AGENTS | MALLINCKRODT INC. (US) | 2002-04-25 | — | — | WO | disclosed |
| WO-2002032466-A1 | LIGHT SENSITIVE COMPOUNDS FOR INSTANT DETERMINATION OF ORGAN FUNCTION | MALLINCKRODT INC. (US) | 2002-04-25 | — | — | WO | disclosed |
| WO-2002032464-A1 | NOVEL DYES FOR ORGAN FUNCTION MONITORING | MALLINCKRODT INC. (US) | 2002-04-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080056989-A1 | Novel Dyes for Organ Function Monitoring | TNNI3, TNNT2, TPH1 | CA1 2057/4885CA2 921/4885CA12 988/4885 |
| US-20070140962-A1 | Light Sensitive Compounds for Instant Determination of Organ Function | TNNI3, TNNC1, TNNT2 | CA1 1738/4885CA2 1141/4885CA12 1323/4885 |
| US-20070269368-A1 | HYDROPHILIC LIGHT ABSORBING COMPOSITIONS FOR DETERMINATION OF PHYSIOLOGICAL FUNCTION IN CRITICALLY ILL PATIENTS | TNNI3, IDO1, TPH1 | CA1 1113/4885CA2 994/4885CA12 665/4885 |
| US-20070269373-A1 | HYDROPHILIC LIGHT ABSORBING COMPOSITIONS FOR DETERMINATION OF PHYSIOLOGICAL FUNCTION IN CRITICALLY ILL PATIENTS | TNNI3, IDO1, TPH1 | CA1 1113/4885CA2 994/4885CA12 665/4885 |
| US-20090263327-A1 | MINIMALLY INVASIVE PHYSIOLOGICAL FUNCTION MONITORING AGENTS | TNNI3, MB, TNNT2 | CA1 916/4885CA2 457/4885CA12 358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.