Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pyrophosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA4 | P22748 | 2/20 | 0.35 |
| ▸ | CA5A | P35218 | 2/20 | 0.35 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.35 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrophosphoric Acid SCHEMBL184653 | 1.00 | LMNA (0.35) | LMNACA1CA4CA5ACA5B | |
| Pyrophosphoric Acid SCHEMBL5550827 | 1.00 | LMNA (0.35) | LMNACA1CA4CA5ACA5B | |
| Pyrophosphoric Acid SCHEMBL18670526 | 1.00 | LMNA (0.35) | LMNACA1CA4CA5ACA5B | |
| Pyrophosphoric Acid SCHEMBL59778 | 1.00 | LMNA (0.35) | LMNACA1CA4CA5ACA5B | |
| Pyrophosphoric Acid SCHEMBL11646886 | 0.96 | CA1 (0.33) | LMNACA1CA4CA5ACA5B | |
| Pyrophosphoric Acid SCHEMBL5884527 | 0.96 | CA1 (0.33) | LMNACA1CA4CA5ACA5B | |
| Pyrophosphoric Acid SCHEMBL7106242 | 0.96 | CA1 (0.33) | LMNACA1CA4CA5ACA5B | |
| Pyrophosphoric Acid SCHEMBL11779407 | 0.96 | CA1 (0.33) | LMNACA1CA4CA5ACA5B | |
| Pyrophosphoric Acid SCHEMBL9422113 | 0.96 | CA1 (0.33) | LMNACA1CA4CA5ACA5B | |
| Pyrophosphoric Acid SCHEMBL452253 | 0.96 | CA1 (0.33) | LMNACA1CA4CA5ACA5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1635741-B1 | PROSTHETIC DEVICE FOR CARTILAGE REPAIR | ROBERT MATHYS STIFTUNG (CH) | 2009-04-15 | — | — | EP | claimed |
| EP-1491164-B1 | Prosthetic device for cartilage repair | ROBERT MATHYS FOUNDATION DR H (CH) | 2008-05-28 | — | — | EP | claimed |