Pyrophosphoric Acid

Pyrophosphoric Acid

SCHEMBL452253

O.O.O=P([O-])([O-])OP(=O)([O-])[O-].[Ca+2].[Ca+2]

nearest known ligand 0.33

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Pyrophosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CA1 P00915 2/20 0.33
CA4 P22748 2/20 0.33
CA5A P35218 2/20 0.33
CA5B Q9Y2D0 2/20 0.33
LMNA P02545 1/20 0.33
SLC34A1 Q06495 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pyrophosphoric Acid SCHEMBL11779407 1.00 CA1 (0.33) CA1CA4CA5ACA5BLMNA
Pyrophosphoric Acid SCHEMBL9422113 1.00 CA1 (0.33) CA1CA4CA5ACA5BLMNA
Pyrophosphoric Acid SCHEMBL1666234 1.00 CA1 (0.33) CA1CA4CA5ACA5BLMNA
Pyrophosphoric Acid SCHEMBL7106242 1.00 CA1 (0.33) CA1CA4CA5ACA5BLMNA
Pyrophosphoric Acid SCHEMBL27905891 0.96 CA1 (0.32) CA1CA4CA5ACA5BLMNA
Pyrophosphoric Acid SCHEMBL5051591 0.96 CA1 (0.32) CA1CA4CA5ACA5BLMNA
Pyrophosphoric Acid SCHEMBL3409500 0.96 CA1 (0.32) CA1CA4CA5ACA5BLMNA
Pyrophosphoric Acid SCHEMBL4418857 0.96 LMNA (0.35) CA1CA4CA5ACA5BLMNA
Pyrophosphoric Acid SCHEMBL18670526 0.96 LMNA (0.35) CA1CA4CA5ACA5BLMNA
Pyrophosphoric Acid SCHEMBL184653 0.96 LMNA (0.35) CA1CA4CA5ACA5BLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1783 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4565326-A1 NLRP3 INFLAMMASOME INHIBITORS Novartis AG (CH) 2025-06-11 EP claimed
WO-2025090498-A1 ENCAPSULATED MEDIUM CHAIN FATTY ACID SALTS AND ORAL SOLID DOSAGE FORMS DERIVED THEREFROM ISP INVESTMENTS LLC (US) 2025-05-01 WO claimed
US-12268733-B2 Methods of treating neurofibromatosis type 1 and related conditions with alkaline phosphatase ALEXION PHARMACEUTICALS, INC. (US) 2025-04-08 US claimed
CN-119677725-A NLRP3 inflammatory corpuscle inhibitor 诺华股份有限公司 2025-03-21 CN claimed
WO-2025042830-A1 PLATELET-DERIVED GROWTH FACTOR BONE GRAFT PUTTY FORMULATION BIOMIMETIC THERAPEUTICS, LLC (US) 2025-02-27 WO claimed
WO-2025034540-A1 IMMUNOSUPPRESSIVE THERAPY TO MITIGATE ANTI-SOLUBLE ALKALINE PHOSPHATASE IMMUNE RESPONSE ALEXION PHARMACEUTICALS, INC. (US) 2025-02-13 WO claimed
US-20250034114-A1 NLRP3 INFLAMMASOME INHIBITORS NOVARTIS AG (CH) 2025-01-30 US claimed
US-20240390558-A1 PLATE-DERIVED GROWTH FACTOR FORMULATION FOR ENHANCING BONE FUSION STRYKER CORPORATION 2024-11-28 US claimed
EP-3500289-B1 ASFOTASE ALFA FOR USE IN TREATING TRACHEOBRONCHOMALACIA ALEXION PHARMA INC (US) 2024-10-09 EP claimed
US-20240216386-A1 MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE REDX PHARMA LIMITED (GB) 2024-07-04 US claimed
US-6287341-B1 MIXING A REACTIVE AMORPHOUS CALCIUM PHOSPHATE, A SECOND CALCIUM PHOSPHATE THAT HAS A CALCIUM TO PHOSPHATE RATIO OF >OR =1.67, AND A PHYSIOLOGICAL LIQUID IN THE AMOUNT TO PROVIDE A PASTE OR PUTTY; INTRODUCING INTO AN IMPLANT SITE ETEX CORPORATION 2001-09-11 US claimed
US-6277151-B1 USING IN VIVO AN AMORPHOUS, HYDRATED CALCIUM PHOSPATE IN AN AQUEOUS SOLUTION OF A PASTE OR PUTTY CONSISTENCY; HAVING A BIOCOMPATIBILITY WITH THE CARTILAGE-FORMING CELL OR PRECURSOR; HARDENING ETEX CORPORATION 2001-08-21 US claimed
WO-2001020018-A2 DIAGNOSING AND TREATING ARTHRITIC DISORDERS MITOKOR (US) 2001-03-22 WO claimed
EP-0941079-A1 BIOCERAMIC COMPOSITIONS ETEX CORPORATION (US) 1999-09-15 EP claimed
EP-0936929-A2 METHOD OF PREPARING A POORLY CRYSTALLINE CALCIUM PHOSPHATE AND METHODS OF ITS USE ETEX CORPORATION (US) 1999-08-25 EP claimed
WO-1998016209-A9 BIOCERAMIC COMPOSITIONS 1998-08-13 WO claimed
WO-1998016209-A2 BIOCERAMIC COMPOSITIONS ETEX CORPORATION (US) 1998-04-23 WO claimed
WO-1998016268-A2 METHOD OF PREPARING A POORLY CRYSTALLINE CALCIUM PHOSPHATE AND METHODS OF ITS USE ETEX CORPORATION (US) 1998-04-23 WO claimed
US-4678662-A IMPROVED TASTE AND FLUORIDE ION STABILITY MONSANTO COMPANY (US) 1987-07-07 US claimed
EP-0175286-A2 In vitro cell culture system and method MCW Research Foundation, Inc. (US) 1986-03-26 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240216386-A1 MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE ROCK2, ROCK1, RHOA CA1 4161/4885CA4 3858/4885CA5A 1499/4885
US-20250034114-A1 NLRP3 INFLAMMASOME INHIBITORS NLRP3, NLRP1, NOD1 CA1 4848/4885CA4 4815/4885CA5A 3667/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.