Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | HTR2C | P28335 | 3/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4423695 | 0.90 | HTR2A (0.41) | HTR2AHTR2CSLC6A4ALDH1A1KMT2A | |
| SCHEMBL4417093 | 0.88 | MAPT (0.43) | HTR2AHTR2CSLC6A4ALDH1A1HSD17B10 | |
| SCHEMBL4418725 | 0.88 | HTR2A (0.46) | HTR2AHTR2CSLC6A4 | |
| SCHEMBL4423636 | 0.88 | ALDH1A1 (0.47) | HTR2AHTR2CSLC6A4SMN1; SMN2ALDH1A1 | |
| SCHEMBL4425227 | 0.86 | CNR1 (0.41) | HTR2AHTR2CSLC6A4ALDH1A1HSD17B10 | |
| SCHEMBL4429829 | 0.85 | FAAH (0.43) | HTR2AHTR2CSLC6A4TP53ALDH1A1 | |
| SCHEMBL4417423 | 0.85 | MGLL (0.43) | HTR2AHTR2CSLC6A4TP53ALDH1A1 | |
| SCHEMBL4423191 | 0.85 | NCEH1 (0.41) | HTR2AHTR2CSLC6A4TP53SMN1; SMN2 | |
| SCHEMBL3922325 | 0.85 | HTR2A (0.62) | HTR2AHTR2CSLC6A4ALDH1A1KMT2A | |
| SCHEMBL4419276 | 0.84 | ACHE (0.39) | HTR2AHTR2CSLC6A4ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583742-B1 | CB 1 RECEPTOUR INVERSE AGONISTS | HOFFMANN LA ROCHE (CH) | 2009-12-02 | — | — | EP | claimed |