SCHEMBL442910

SCHEMBL442910

O=S(=O)(Cl)c1cccc(OC(F)(F)F)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC40A1 Q9NP59 1/20 0.48
KAT6A Q92794 4/20 0.48
PTGES2 Q9H7Z7 3/20 0.45
SLC22A12 Q96S37 1/20 0.43
HDAC3 O15379 1/20 0.43
HDAC4 P56524 1/20 0.43
HDAC1 Q13547 1/20 0.43
HDAC7 Q8WUI4 1/20 0.43
HDAC2 Q92769 1/20 0.43
HDAC10 Q969S8 1/20 0.43
HDAC11 Q96DB2 1/20 0.43
HDAC8 Q9BY41 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
HDAC9 Q9UKV0 1/20 0.43
HDAC5 Q9UQL6 1/20 0.43
FBP1 P09467 1/20 0.43
ALDH1A1 P00352 1/20 0.42
HSD17B10 Q99714 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
KDM2B Q8NHM5 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6426425 0.85 PIM1 (0.41) SLC40A1KAT6APTGES2ALDH1A1HSD17B10
SCHEMBL8075337 0.82 CA2 (0.55) SLC40A1KAT6APTGES2
SCHEMBL22545576 0.82 KAT6A (0.51) SLC40A1KAT6APTGES2SLC22A12HDAC3
SCHEMBL862985 0.82 ABL1 (0.49) SLC40A1KAT6APTGES2SLC22A12HDAC3
SCHEMBL4190483 0.81 FFAR4 (0.38) SLC40A1KAT6APTGES2SLC22A12FBP1
Hydrochloric Acid SCHEMBL27913690 0.81 KAT6A (0.50) SLC40A1KAT6APTGES2SLC22A12HDAC3
SCHEMBL22954096 0.81 KAT6A (0.53) SLC40A1KAT6APTGES2SLC22A12NAMPT
SCHEMBL14572884 0.79 KDM2B (0.48) SLC40A1KAT6APTGES2HDAC3HDAC4
SCHEMBL9778961 0.79 PTGES2 (0.52) SLC40A1KAT6APTGES2SLC22A12HDAC3
SCHEMBL27383227 0.79 SLC22A12 (0.43) SLC40A1KAT6APTGES2SLC22A12CHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 383 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119320374-B Method for synthesizing 3-sulfonyl substituted chromone derivative by photocatalysis JIANG University OF TECHNOLOGY (CN) 2026-05-26 CN disclosed
US-12630548-B2 Azetidine derivatives for the treatment of integrin associated diseases THE UNIVERSITY OF NOTTINGHAM (GB) 2026-05-19 US disclosed
US-12630529-B2 GCN2 modulator compounds Alesta Therapeutics BV (NL) 2026-05-19 US disclosed
EP-4596534-A1 NONCOVALENT SMALL-MOLECULE INHIBITORS OF THE KEAP1-NRF2 INTERACTION University of Copenhagen (DK) 2025-08-06 EP disclosed
EP-3728194-B1 QUINOLINE SULFONAMIDE COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS OTAGO INNOVATION LTD (NZ) 2025-06-04 EP disclosed
WO-2025104079-A1 SALICYLIC ACID AND PICOLINIC ACID DERIVATIVES AS INHIBITORS OF ENERGY COUPLING FACTOR (ECF) TRANSPORTERS FOR THE TREATMENT OF BACTERIAL INFECTIONS Helmholtz-Zentrum für Infektionsforschung GmbH (DE) 2025-05-22 WO disclosed
US-20250099448-A1 HETEROCYCLIC COMPOUNDS HOFFMANN-LA ROCHE INC. (US) 2025-03-27 US disclosed
CN-119462588-A Flavone derivative containing sulfonamide structure and preparation method and application thereof 上海中医药大学附属曙光医院 2025-02-18 CN disclosed
CN-119320374-A Method for synthesizing 3-sulfonyl substituted chromone derivative by photocatalysis 浙江工业大学 2025-01-17 CN disclosed
EP-4469446-A1 NEW HETEROCYCLIC COMPOUNDS F. Hoffmann-La Roche AG (CH) 2024-12-04 EP disclosed
US-20040180892-A1 Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists ENCYSIVE PHARMACEUTICALS INC. 2004-09-16 US disclosed
US-20040106667-A1 Substituted indazoles, compositions containing them, method of production and use AVENTIS PHARMA S.A. (FR) 2004-06-03 US disclosed
US-20030229119-A1 Antagonists of melanin concentrating hormone effects on the melanin concetrating hormone receptor ABBVIE INC. 2003-12-11 US disclosed
US-20030176461-A1 Aminopiperidines NPS ALLELIX CORP. (CANADA CORPORATION) (CA) 2003-09-18 US disclosed
US-20030166649-A1 Methods for treating arthritic disorders WYETH 2003-09-04 US disclosed
WO-2003070244-A1 ANTAGONIST OF MELANIN CONCENTRATING HORMONE AND THEIR USES ABBOTT LABORATORIES (US) 2003-08-28 WO disclosed
US-20030149029-A1 Methods for treating asthmatic conditions WYETH 2003-08-07 US disclosed
US-20030144282-A1 Inhibitors of cytosolic phospholipase A2 WYETH 2003-07-31 US disclosed
EP-1296950-A2 AMINOPIPERIDINES FOR USE AS GLYT-1 INHIBITORS NPS Allelix Corp. (CA) 2003-04-02 EP disclosed
WO-2001081308-A2 AMINOPIPERIDINES FOR USE AS GLYT-1 INHIBITORS NPS ALLELIX CORP. (CA) 2001-11-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12630529-B2 GCN2 modulator compounds NR3C1, GCN1, EIF2AK4 SLC40A1 2458/4885KAT6A 432/4885PTGES2 2076/4885
US-20040106667-A1 Substituted indazoles, compositions containing them, method of production and use ABL1, CDK3, CILK1 SLC40A1 4501/4885KAT6A 1846/4885PTGES2 2520/4885
US-20030229119-A1 Antagonists of melanin concentrating hormone effects on the melanin concetrating hormone receptor MCHR1, MCHR2, MC1R SLC40A1 719/4885KAT6A 3450/4885PTGES2 4803/4885
US-20040180892-A1 Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists CCR9, CCR1, CCRL2 SLC40A1 3214/4885KAT6A 4521/4885PTGES2 516/4885
US-20250099448-A1 HETEROCYCLIC COMPOUNDS OPRM1, CYP1A1, CYP3A4 SLC40A1 1814/4885KAT6A 727/4885PTGES2 2731/4885
US-20030176461-A1 Aminopiperidines SLC1A2, SLC6A4, SLC1A1 SLC40A1 323/4885KAT6A 827/4885PTGES2 2870/4885
US-12630548-B2 Azetidine derivatives for the treatment of integrin associated diseases ITGA2, ITGB2, ITGB1 SLC40A1 2772/4885KAT6A 862/4885PTGES2 1302/4885
US-20030166649-A1 Methods for treating arthritic disorders PLA2G12A, PLA2G4A, PLA2G4B SLC40A1 3649/4885KAT6A 1291/4885PTGES2 35/4885
US-20030149029-A1 Methods for treating asthmatic conditions PLA2G4A, PLA2G4B, PLA2G1B SLC40A1 4580/4885KAT6A 1346/4885PTGES2 27/4885
US-20030144282-A1 Inhibitors of cytosolic phospholipase A2 PLA2G4A, PLA2G4B, PLA2G4C SLC40A1 3579/4885KAT6A 2910/4885PTGES2 26/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.