Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phthalimide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.45 |
| ▸ | PPARG known ✓ | P37231 | 1/20 | 0.45 |
| ▸ | CA1 known ✓ | P00915 | 1/20 | 0.38 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | CDC25B | P30305 | 3/20 | 0.47 |
| ▸ | MAOA | P21397 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | S100A4 | P26447 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | APAF1 | O14727 | 2/20 | 0.45 |
| ▸ | TDP2 | O95551 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CES1 | P23141 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | BLM | P54132 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phthalimide SCHEMBL543799 | 0.94 | KMT2A (0.47) | KMT2AMEN1CDC25BMAOAPOLB | |
| Phthalimide SCHEMBL5742515 | 0.94 | KMT2A (0.47) | KMT2AMEN1CDC25BMAOAPOLB | |
| Phthalimide SCHEMBL9230 | 0.94 | KMT2A (0.47) | KMT2AMEN1CDC25BMAOAPOLB | |
| Phthalimide SCHEMBL228978 | 0.94 | KMT2A (0.47) | KMT2AMEN1CDC25BMAOAPOLB | |
| Phthalimide SCHEMBL4948701 | 0.94 | KMT2A (0.47) | KMT2AMEN1CDC25BMAOAPOLB | |
| Phthalimide SCHEMBL30464238 | 0.94 | KMT2A (0.47) | KMT2AMEN1CDC25BMAOAPOLB | |
| Phthalimide SCHEMBL7521029 | 0.94 | KMT2A (0.47) | KMT2AMEN1CDC25BMAOAPOLB | |
| Phthalimide SCHEMBL9137612 | 0.94 | KMT2A (0.47) | KMT2AMEN1CDC25BMAOAPOLB | |
| Phthalimide SCHEMBL10592854 | 0.91 | KMT2A (0.45) | KMT2AMEN1CDC25BMAOAPOLB | |
| Phthalimide SCHEMBL6890308 | 0.91 | KMT2A (0.45) | KMT2AMEN1CDC25BMAOAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 311 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250115585-A1 | METHOD FOR PRODUCING DIHYDROPYRIDAZINE-3,5-DIONE DERIVATIVE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2025-04-10 | — | — | US | claimed |
| CN-119330870-A | Synthesis method of N-cyclohexyl thio-phthalic acid amide | 山东鑫生工贸有限公司 | 2025-01-21 | — | — | CN | claimed |
| CN-119039201-A | Synthesis method of (S) -1-tert-butoxycarbonyl-3-aminopyrrolidine | 苏州汉德创宏生化科技有限公司 | 2024-11-29 | — | — | CN | claimed |
| CN-118762939-A | Preparation and application of low-cost oxygen/nitrogen co-doped self-activated porous carbon nano sheet composite electrode material | 重庆市潼南区生态环境监测站 | 2024-10-11 | — | — | CN | claimed |
| CN-117986213-A | Method for preparing 2, 5-di (aminomethyl) furan from 5-chloromethyl furfural | 厦门大学 | 2024-05-07 | — | — | CN | claimed |
| EP-4353718-A1 | METHOD FOR PRODUCING DIHYDROPYRIDAZINE-3,5-DIONE DERIVATIVE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2024-04-17 | — | — | EP | claimed |
| CN-117486758-A | Preparation method of (1S, 3S) -3-aminocycloamyl carbamic acid tert-butyl ester | 南京正济医药研究有限公司 | 2024-02-02 | — | — | CN | claimed |
| CN-117460727-A | Process for producing dihydropyridazine-3, 5-dione derivative | 中外制药株式会社 | 2024-01-26 | — | — | CN | claimed |
| CN-116926632-A | Nickel electroplating liquid, preparation method and application thereof | 信维电子科技(益阳)有限公司 | 2023-10-24 | — | — | CN | claimed |
| CN-116715631-A | Preparation method of cis-trans isomer of spiro [ cyclobutane 1,4' -isoquinoline ] ketone derivative | 苏州恩华生物医药科技有限公司 | 2023-09-08 | — | — | CN | claimed |
| EP-2548859-A1 | PREPARATION METHODS OF METHYL-D3-AMINE AND SALTS THEREOF | Suzhou Zelgen Biopharmaceutical Co., Ltd. (CN) | 2013-01-23 | — | — | EP | claimed |
| US-20130018209-A1 | PREPARATION METHODS OF METHYL-D3-AMINE AND SALTS THEREOF | SUZHOU ZELGEN BIOPHARMACEUTICAL CO., LTD. (CN) | 2013-01-17 | — | — | US | claimed |
| WO-2012063126-A2 | IMPROVED PROCESSES FOR PREPARING PURE (3AR,4S,6R,6AS)-6-AMINO-2,2-DIMETHYLTETRAHDRO-3AH-CYCLOPENTA[D] [1,3]-DIOXOL-4-OL AND ITS KEY STARTING MATERIAL | ACTAVIS GROUP PTC EHF (IS) | 2012-05-18 | — | — | WO | claimed |
| WO-2012032533-A2 | PROCESSES FOR THE PREPARATION OF 4-{4-[5(S)-(AMINOMETHYL)-2-OXO-1,3-OXAZOLIDIN-3-YL]PHENYL} MORPHOLIN-3-ONE | SYMED LABS LIMITED (IN) | 2012-03-15 | — | — | WO | claimed |
| WO-2011158249-A1 | PROCESS FOR PREPARATION OF MILNACIPRAN INTERMEDIATE AND ITS USE IN PREPARATION OF PURE MILNACIPRAN | GLENMARK GENERICS LIMITED (IN) | 2011-12-22 | — | — | WO | claimed |
| WO-2009128088-A2 | PREPARATION OF 2-(2-ALKOXY PHENOXY) ETHYLAMINE, AN INTERMEDIATE OF CARVEDILOL AND TAMSULOSIN | SHODHANA LABORATORIES LIMITED (IN) | 2009-10-22 | — | — | WO | claimed |
| US-6613488-B1 | Metal-free- or titanyloxy- phthalocyanine compound and phthalimide salt | FUJI ELECTRIC IMAGING DEVICES CO., LTD. (JP) | 2003-09-02 | — | — | US | claimed |
| EP-0446913-B1 | Process for the preparation of chlorothiazole derivatives | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-06-04 | — | — | EP | claimed |
| US-5180833-A | PROCESS FOR THE PREPARATION OF CHLOROTHIAZOLE DERIVATIVES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-01-19 | — | — | US | claimed |
| EP-0446913-A1 | Process for the preparation of chlorothiazole derivatives | Takeda Chemical Industries, Ltd. (JP) | 1991-09-18 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250115585-A1 | METHOD FOR PRODUCING DIHYDROPYRIDAZINE-3,5-DIONE DERIVATIVE | QDPR, DHPS, DPYD | THRB 4718/4885PPARG 3333/4885CA1 2544/4885 |
| US-20130018209-A1 | PREPARATION METHODS OF METHYL-D3-AMINE AND SALTS THEREOF | NSD3, CCND3, DRD3 | THRB 849/4885PPARG 936/4885CA1 914/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.