SCHEMBL4435885

SCHEMBL4435885

O=S(=O)([O-])CCCCOCc1ccccc1.[Na+]

nearest known ligand 0.48

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CA1 known ✓ P00915 1/20 0.41
CA2 known ✓ P00918 1/20 0.41
MGLL Q99685 2/20 0.48
TSHR P16473 1/20 0.45
L3MBTL1 Q9Y468 2/20 0.44
TDP1 Q9NUW8 1/20 0.44
PABPC1 P11940 1/20 0.42
EIF4H Q15056 1/20 0.42
CTDSP1 Q9GZU7 1/20 0.42
CA9 Q16790 1/20 0.41
HRH4 Q9H3N8 1/20 0.40
HRH3 Q9Y5N1 1/20 0.40
EPHX2 P34913 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18631331 0.88 TSHR (0.50) MGLLTSHRCA1CA2CA9
SCHEMBL4444788 0.85 MGLL (0.43) MGLLL3MBTL1TDP1CA2
SCHEMBL4438964 0.85 CA1 (0.45) MGLLPABPC1EIF4HCTDSP1CA1
SCHEMBL4434540 0.85 MEN1 (0.45) CA2HRH3
SCHEMBL23461595 0.85 TSHR (0.47) MGLLTSHRCA1CA2CA9
SCHEMBL6598977 0.81 MGLL (0.49) MGLLTSHRL3MBTL1TDP1CA1
SCHEMBL31061188 0.80 MGLL (0.48) MGLLTSHRL3MBTL1TDP1CA1
SCHEMBL22071071 0.80 CA2 (0.49) MGLLTSHRL3MBTL1TDP1CA1
SCHEMBL22070850 0.80 MGLL (0.48) MGLLTSHRL3MBTL1TDP1CA1
SCHEMBL4435889 0.80 MGLL (0.48) MGLLTSHRL3MBTL1TDP1CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101600823-A Wettable polyester fibers and fabric CIBA HOLDING INC (CH) 2009-12-09 CN disclosed
EP-2122020-A1 WETTABLE POLYESTER FIBERS AND FABRICS Ciba Holding Inc. (CH) 2009-11-25 EP disclosed
WO-2008090060-A1 WETTABLE POLYESTER FIBERS AND FABRICS CIBA HOLDING INC. (CH) 2008-07-31 WO disclosed
US-20080176475-A1 Wettable polyester fibers and fabrics CIBA CORP. 2008-07-24 US disclosed