SCHEMBL4453981

SCHEMBL4453981

O=C(O)CCc1ccc(O)c(-n2nc3ccccc3n2)c1

nearest known ligand 0.70

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.52
LMNA P02545 1/20 0.52
RAB9A P51151 1/20 0.52
FFAR1 O14842 11/20 0.46
PLA2G4A P47712 1/20 0.46
KEAP1 Q14145 1/20 0.45
RHOA P61586 1/20 0.43
FFAR4 Q5NUL3 3/20 0.41
APP P05067 1/20 0.40
KDM4E B2RXH2 1/20 0.40
ALDH1A1 P00352 1/20 0.40
POLB P06746 1/20 0.40
HPGD P15428 1/20 0.40
ALOX15 P16050 1/20 0.40
MAPK1 P28482 1/20 0.40
HSD17B10 Q99714 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20599212 0.91 CYP1A2 (0.46) NPC1LMNARAB9AFFAR1PLA2G4A
SCHEMBL8647506 0.86 FFAR1 (0.42) NPC1LMNARAB9AFFAR1KDM4E
SCHEMBL11612733 0.86 LMNA (0.55) NPC1LMNARAB9AKDM4EALDH1A1
SCHEMBL5693424 0.84 LMNA (0.51) NPC1LMNARAB9AAPPKDM4E
SCHEMBL20598275 0.84 PLA2G4A (0.41) NPC1LMNARAB9AFFAR1PLA2G4A
SCHEMBL20598220 0.83 NPC1 (0.50) NPC1LMNARAB9AAPPKDM4E
SCHEMBL18932577 0.83 MMP12 (0.50) NPC1LMNARAB9APLA2G4AAPP
SCHEMBL8786914 0.83 RXRA (0.44) NPC1LMNARAB9AFFAR4
SCHEMBL29517159 0.82 LMNA (0.58) NPC1LMNARAB9AKDM4EALDH1A1
SCHEMBL77763 0.82 LMNA (0.58) NPC1LMNARAB9AKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025033541-A1 RESIN COMPOSITION, PELLETS, AND MOLDED ARTICLE 三菱ケミカル株式会社 2025-02-13 WO disclosed
US-12178938-B2 UV absorbing ocular lens SEED CO., LTD. (JP) 2024-12-31 US disclosed
EP-3894909-B1 UV ABSORBING OCULAR LENS SEED CO LTD (JP) 2024-07-31 EP disclosed
CN-113316727-B UV absorbing ophthalmic lenses 株式会社实瞳 2024-07-09 CN disclosed
WO-2024117159-A1 RESIN COMPOSITION, PELLET, MOLDED ARTICLE, AND METHOD FOR PRODUCING RESIN COMPOSITION 三菱ケミカル株式会社 2024-06-06 WO disclosed
WO-2024117158-A1 RESIN COMPOSITION, PELLETS AND MOLDED ARTICLE 三菱ケミカル株式会社 2024-06-06 WO disclosed
EP-3894909-A1 UV ABSORBING OCULAR LENS Seed Co., Ltd. (JP) 2021-10-20 EP disclosed
CN-113316727-A UV absorbing ophthalmic lenses 株式会社实瞳 2021-08-27 CN disclosed
EP-3383854-B1 WATER-SOLUBLE UV-ABSORBING COMPOUNDS AND USES THEREOF ALCON INC (CH) 2021-03-03 EP disclosed
US-10823983-B2 UV-absorbing vinylic monomers and uses thereof ALCON INC. (CH) 2020-11-03 US disclosed
US-6803395-B2 POLYSILOXANE HAVING THEREON A HYDROPHILIC MOIETY AND A LIGHTFASTNESS MOIETY XEROX CORPORATION 2004-10-12 US disclosed
US-20030137570-A1 Photoprotective and lightfastness-enhancing siloxanes XEROX CORPORATION 2003-07-24 US disclosed
US-20030133886-A1 Photoprotective and lightfastness-enhancing siloxanes XEROX CORPORATION 2003-07-17 US disclosed
US-20030098440-A1 Adhesion promoters containing benzotriazoles HENKEL AG & CO. KGAA (DE) 2003-05-29 US disclosed
US-6569511-B1 Polysiloxane having a hydrophilic moiety and a lightfastness moiety; ink jet coating XEROX CORPORATION 2003-05-27 US disclosed
WO-2003029227-A1 ADHESION PROMOTERS CONTAINING BENZOTRIAZOLES NATIONAL STARCH AND CHEMICAL INVESTMENT HOLDING CORPORATION (US) 2003-04-10 WO disclosed
US-20020102369-A1 Cellulose ester film, cellulose ester dope, protective film of polarizing plate and polarizing plate KONICA CORPORATION. 2002-08-01 US disclosed
EP-0296391-B1 LIGHT-STABILIZED POLYMER MICROPARTICLES CONTAINING EPOXY GROUPS CIBA-GEIGY AG (CH) 1993-07-07 EP disclosed
US-4894399-A Light-stabilized polymer microparticles containing epoxy groups CIBA-GEIGY CORPORATION (US) 1990-01-16 US disclosed
EP-0296391-A2 Light-stabilized polymer microparticles containing epoxy groups CIBA-GEIGY AG (CH) 1988-12-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10823983-B2 UV-absorbing vinylic monomers and uses thereof UACA, VCL, CRYZ NPC1 4585/4885LMNA 924/4885RAB9A 1944/4885
US-20030133886-A1 Photoprotective and lightfastness-enhancing siloxanes ITGA1, ITGB1, ITGB8 NPC1 4021/4885LMNA 296/4885RAB9A 1019/4885
US-12178938-B2 UV absorbing ocular lens UACA, PHYKPL, UROD NPC1 4839/4885LMNA 243/4885RAB9A 4106/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.