Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1A1 | P14550 | 19/20 | 1.00 |
| ▸ | AKR1B1 | P15121 | 19/20 | 1.00 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL421176 | 0.92 | AKR1B1 (1.00) | AKR1A1AKR1B1PTGDR2 | |
| SCHEMBL421004 | 0.88 | AKR1B1 (1.00) | AKR1A1AKR1B1 | |
| SCHEMBL443331 | 0.81 | AKR1B1 (1.00) | AKR1A1AKR1B1 | |
| Lidorestat SCHEMBL419032 | 0.77 | AKR1A1 (1.00) | AKR1A1AKR1B1 | |
| Lidorestat SCHEMBL29387869 | 0.77 | AKR1A1 (1.00) | AKR1A1AKR1B1 | |
| Lidorestat SCHEMBL6103908 | 0.76 | AKR1A1 (0.98) | AKR1A1AKR1B1 | |
| SCHEMBL443930 | 0.73 | AKR1A1 (1.00) | AKR1A1AKR1B1 | |
| SCHEMBL420984 | 0.72 | AKR1A1 (1.00) | AKR1A1AKR1B1 | |
| SCHEMBL18022733 | 0.71 | PTGDR2 (0.63) | AKR1A1AKR1B1PTGDR2 | |
| SCHEMBL9701519 | 0.71 | KMT2A (0.60) | AKR1A1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214540-A1 | 3-[(phenyl or benzothiazol-2-yl)methyl]indole-N-acetic acids and esters; analgesics; aldose reductase inhibitors; diabetes complications including cataracts, retinopathy, nephropathy, and neuropathy; side effect reduction | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY, LLC | 2008-09-04 | — | — | US | claimed |
| US-20060074114-A1 | Methods of reducing serum glucose and triglyceride levels and for inhibiting angiogenesis using substituted indolealkanoic acids | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, INC. | 2006-04-06 | — | — | US | claimed |
| CN-1205207-C | Substituted indolealkanoic acids | INST FOR PHARMACEUTICAL DESCOV (US) | 2005-06-08 | — | — | CN | claimed |
| US-20040235933-A1 | Substituted indolealkanoic acids | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY LLC | 2004-11-25 | — | — | US | claimed |
| EP-1066283-B1 | SUBSTITUTED INDOLEALKANOIC ACIDS | INST FOR PHARM DISCOVERY INC (US) | 2004-06-23 | — | — | EP | claimed |
| US-6730794-B2 | Substituted indolealkanoic acids | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY, LLC. | 2004-05-04 | — | — | US | claimed |
| EP-1135124-B1 | ANTIHYPERTRIGLYCERIDEMIC, ANTIHYPERGLYCEMIC, ANTI-ANGIOGENIC AND WOUND HEALING SUBSTITUDED INDOLEALKANOIC ACIDS | INST FOR PHARM DISCOVERY INC (US) | 2004-04-28 | — | — | EP | claimed |
| US-20030216452-A1 | Method of reducing serum glucose and triglyceride levels and for inhibiting angiogenesis using substitute indolealkanoic acids | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY, INC. | 2003-11-20 | — | — | US | claimed |
| US-20030171405-A1 | Compositions containing a substituted indolealkanoic acid and an angiotensin converting enzyme inhibitor | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY LLC., A CORPORATION OF THE STATE OF DELAWARE | 2003-09-11 | — | — | US | claimed |
| US-6555568-B1 | 3-(4,5,7-trifluorobenzothiazol-2-yl)methyl-indole-N-acetic acid, ethyl ester for example; treating angiogenesis, hyperglycemia, hyperlipidemia and chronic complications arising from diabetes mellitus | INSTITUTE FOR PHARMACEUTICAL DISCOVERY, L.L.C. | 2003-04-29 | — | — | US | claimed |
| US-20010044437-A1 | Methods for reducing uric acid levels | INSTITUTE FOR PHARMACEUTICAL DISCOVERY LLC, THE | 2001-11-22 | — | — | US | claimed |
| US-20010041722-A1 | Compositions containing a substituted indolealkanoic acid and an angiotensin converting enzyme inhibitor | ALINEA PHARMACEUTICALS, INC. | 2001-11-15 | — | — | US | claimed |
| EP-1135124-A2 | ANTIHYPERTRIGLYCERIDEMIC, ANTIHYPERGLYCEMIC, ANTI-ANGIOGENIC AND WOUND HEALING SUBSTITUDED INDOLEALKANOIC ACIDS | The Institutes for Pharmaceutical Discovery, Inc. (US) | 2001-09-26 | — | — | EP | claimed |
| WO-2001064205-A2 | COMPOSITIONS CONTAINING A SUBSTITUTED INDOLEALKANOIC ACID AND AN ANGIOTENSIN CONVERTING ENZYME INHIBITOR | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2001-09-07 | — | — | WO | claimed |
| US-20010016661-A1 | Substituted indolealkanoic acids | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY | 2001-08-23 | — | — | US | claimed |
| CN-1296485-A | Substituted indolealkanoic acids | INST FOR PHARM DISCOVERY INC (US) | 2001-05-23 | — | — | CN | claimed |
| US-6214991-B1 | 3-(4,5,7-TRIFLUOROBENZOTHIAZOL-2-YL)METHYL-INDOLE-N-ACETIC ACID, ETHYL ESTER FOR EXAMPLE; TREATING COMPLICATIONS OF DIABETES MELLITUS, SUCH AS CATARACTS, RETINOPATHY, NEPHROPATHY, AND NEUROPATHY | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY, INC. | 2001-04-10 | — | — | US | claimed |
| EP-1066283-A2 | SUBSTITUTED INDOLEALKANOIC ACIDS | The Institutes for Pharmaceutical Discovery, Inc. (US) | 2001-01-10 | — | — | EP | claimed |
| WO-2000032180-A2 | ANTIHYPERTRIGLYCERIDEMIC, ANTIHYPERGLYCEMIC, ANTI-ANGIOGENIC AND WOUND HEALING SUBSTITUTED INDOLEALKANOIC ACIDS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, INC. (US) | 2000-06-08 | — | — | WO | claimed |
| WO-1999050268-A2 | SUBSTITUTED INDOLEALKANOIC ACIDS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, INC. (US) | 1999-10-07 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010016661-A1 | Substituted indolealkanoic acids | GPR119, AANAT, AADAT | AKR1A1 475/4885AKR1B1 419/4885PTGDR2 349/4885 |
| US-20030216452-A1 | Method of reducing serum glucose and triglyceride levels and for inhibiting angiogenesis using substitute indolealkanoic acids | LIPG, PNLIP, LIPA | AKR1A1 513/4885AKR1B1 475/4885PTGDR2 617/4885 |
| US-20030171405-A1 | Compositions containing a substituted indolealkanoic acid and an angiotensin converting enzyme inhibitor | AGT, LIPG, ACE | AKR1A1 203/4885AKR1B1 185/4885PTGDR2 1053/4885 |
| US-20010044437-A1 | Methods for reducing uric acid levels | XDH, LIPA, OAT | AKR1A1 410/4885AKR1B1 207/4885PTGDR2 2771/4885 |
| US-20010041722-A1 | Compositions containing a substituted indolealkanoic acid and an angiotensin converting enzyme inhibitor | AGT, LIPG, ACE | AKR1A1 203/4885AKR1B1 185/4885PTGDR2 1053/4885 |
| US-20060074114-A1 | Methods of reducing serum glucose and triglyceride levels and for inhibiting angiogenesis using substituted indolealkanoic acids | LIPG, PNLIP, LIPA | AKR1A1 549/4885AKR1B1 499/4885PTGDR2 662/4885 |
| US-20040235933-A1 | Substituted indolealkanoic acids | GPR119, AANAT, AADAT | AKR1A1 475/4885AKR1B1 419/4885PTGDR2 349/4885 |
| US-20080214540-A1 | 3-[(phenyl or benzothiazol-2-yl)methyl]indole-N-acetic acids and esters; analgesics; aldose reductase inhibitors; diabetes complications including cataracts, retinopathy, nephropathy, and neuropathy; side effect reduction | AKR1C3, AKR1C2, AKR1B1 | AKR1A1 6/4885AKR1B1 3/4885PTGDR2 601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.