Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19824761 | 0.89 | LTA4H (0.49) | OPRM1OPRD1LTA4HTAAR1KMT2A | |
| SCHEMBL28130228 | 0.88 | NAAA (0.49) | OPRM1OPRD1LTA4HTAAR1KMT2A | |
| Cyclopropane SCHEMBL11656939 | 0.85 | LTA4H (0.46) | OPRM1OPRD1LTA4HTAAR1ALDH1A1 | |
| SCHEMBL1258879 | 0.84 | CYP4F2 (0.58) | TAAR1KMT2ALMNAHTTTDP1 | |
| SCHEMBL111429 | 0.83 | L3MBTL1 (0.54) | KMT2ALMNAALDH1A1HTTMAPT | |
| SCHEMBL29059723 | 0.83 | CTSS (0.43) | OPRM1OPRD1LTA4HTAAR1KMT2A | |
| SCHEMBL6172268 | 0.81 | SLC1A3 (0.43) | OPRM1OPRD1LTA4HTAAR1ALDH1A1 | |
| SCHEMBL3353073 | 0.81 | ALDH1A1 (0.53) | OPRM1OPRD1TAAR1KMT2ALMNA | |
| SCHEMBL20557014 | 0.81 | TDP1 (0.51) | OPRM1OPRD1LTA4HTAAR1ALDH1A1 | |
| SCHEMBL34470938 | 0.81 | TDP1 (0.51) | OPRM1OPRD1LTA4HTAAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103145692-B | Preparation method of 4, 5-dihydro-6H-cyclopenta[b]thiophene-6-ketone | YANCHENG INST TECHNOLOGY | 2014-07-16 | — | — | CN | claimed |
| CN-103145692-A | Preparation method of 4, 5-dihydro-6H-cyclopenta[b]thiophene-6-ketone | YANCHENG INST TECHNOLOGY | 2013-06-12 | — | — | CN | claimed |
| EP-1185524-B1 | 3-HETEROARYLALKYL SUBSTITUTED GABA ANALOGS | WARNER LAMBERT CO (US) | 2005-01-26 | — | — | EP | claimed |
| US-20040127724-A1 | 3-heteroarylalkyl substituted GABA analogs | YUEN PO-WAI (US) | 2004-07-01 | — | — | US | claimed |
| JP-2003500486-A | — | — | 2003-01-07 | — | — | JP | claimed |
| EP-1185524-A2 | 3-HETEROARYLALKYL SUBSTITUTED GABA ANALOGS | WARNER-LAMBERT COMPANY (US) | 2002-03-13 | — | — | EP | claimed |
| WO-2000073296-A2 | 3-HETEROARYLALKYL SUBSTITUTED GABA ANALOGS | WARNER-LAMBERT COMPANY (US) | 2000-12-07 | — | — | WO | claimed |
| CN-103145692-B | Preparation method of 4, 5-dihydro-6H-cyclopenta[b]thiophene-6-ketone | YANCHENG INST TECHNOLOGY | 2014-07-16 | — | — | CN | disclosed |
| CN-103145692-A | Preparation method of 4, 5-dihydro-6H-cyclopenta[b]thiophene-6-ketone | YANCHENG INST TECHNOLOGY | 2013-06-12 | — | — | CN | disclosed |
| US-7524878-B2 | Phenyl substituted carboxylic acids | THE INSTITUTE FOR PHARMACEUTICALS DISCOVERY LLC (US) | 2009-04-28 | — | — | US | disclosed |
| US-7465825-B2 | Phenyl substituted carboxylic acids | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2008-12-16 | — | — | US | disclosed |
| EP-1836182-A2 | HETEROCYCLYLBIPHENYL DERIVATES AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS | The Institutes for Pharmaceutical Discovery, LLC (US) | 2007-09-26 | — | — | EP | disclosed |
| US-20060122257-A1 | Phenyl substituted carboxylic acids | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC | 2006-06-08 | — | — | US | disclosed |
| WO-1989012629-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-12-28 | — | — | WO | disclosed |
| US-4143051-A | GREATER TISSUE SPECIFICITY OF ACTION | PFIZER INC. (US) | 1979-03-06 | — | — | US | disclosed |
| US-4113723-A | TISSUE SPECIFICITY | PFIZER INC. (US) | 1978-09-12 | — | — | US | disclosed |
| US-4102894-A | TISSUE SPECIFICITY | PFIZER INC. (US) | 1978-07-25 | — | — | US | disclosed |
| US-4080368-A | PROSTAGLANDINS | PFIZER INC. (US) | 1978-03-21 | — | — | US | disclosed |
| US-3980642-A | 15-Substitute D-ω-pentanorprostaglandins | PFIZER INC. (US) | 1976-09-14 | — | — | US | disclosed |
| US-3956284-A | INCREASED TISSUE SPECIFITY OF ACTION | PFIZER INC. (US) | 1976-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122257-A1 | Phenyl substituted carboxylic acids | PTPA, PTPRS, PTPRO | OPRM1 4628/4885OPRD1 4510/4885LTA4H 2880/4885 |
| US-20040127724-A1 | 3-heteroarylalkyl substituted GABA analogs | GABRB3, GABRB1, GABRB2 | OPRM1 989/4885OPRD1 452/4885LTA4H 801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.