Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.37 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.36 |
| ▸ | FNTB | P49356 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4492959 | 0.87 | CA12 (0.41) | KDM4EALDH1A1HPGDHSD17B10TDP1 | |
| SCHEMBL4504872 | 0.86 | LDHA (0.38) | PPARGPPARAMMEL3MBTL1FNTA | |
| SCHEMBL4494581 | 0.83 | ESR1 (0.38) | ALDH1A1ALOX5 | |
| SCHEMBL4490045 | 0.83 | PPARG (0.42) | PPARGPPARAKDM4EALDH1A1HPGD | |
| SCHEMBL4485738 | 0.81 | MTNR1A (0.41) | ALDH1A1HPGDMME | |
| SCHEMBL4485668 | 0.78 | ALDH1A1 (0.39) | ALDH1A1FNTAFNTB | |
| SCHEMBL4492334 | 0.77 | TAAR1 (0.36) | HPGDALOX5AKR1C3 | |
| SCHEMBL4559834 | 0.77 | PPARG (0.41) | PPARGPPARAALDH1A1MMEL3MBTL1 | |
| SCHEMBL4481909 | 0.77 | KDM4E (0.40) | KDM4EALDH1A1HPGDTDP1L3MBTL1 | |
| SCHEMBL4485206 | 0.77 | ALDH1A1 (0.32) | KDM4EALDH1A1HPGDHSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504429-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2009-03-17 | — | — | US | claimed |