Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.35 |
| ▸ | TDO2 | P48775 | 2/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GALR3 | O60755 | 1/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3937913 | 0.79 | IDH1 (0.44) | IDH1MEN1KMT2A | |
| SCHEMBL20157086 | 0.72 | HCAR3 (0.56) | IDH1MKNK1MKNK2TDO2KIT | |
| SCHEMBL20156855 | 0.72 | FERMT2 (0.44) | IDH1MAP4K4MKNK1MKNK2TDO2 | |
| SCHEMBL30721187 | 0.68 | HCAR3 (0.53) | IDH1MKNK1MKNK2FFAR2KIT | |
| SCHEMBL4748840 | 0.68 | HCAR3 (0.53) | IDH1MKNK1MKNK2FFAR2KIT | |
| SCHEMBL24661308 | 0.68 | TDO2 (0.41) | IDH1MKNK1MKNK2CRHR1TDO2 | |
| SCHEMBL10055036 | 0.66 | GPR55 (0.60) | RAB9AGPR55 | |
| Hydrochloric Acid SCHEMBL3718104 | 0.66 | ADRA2A (0.53) | IDH1MKNK1MKNK2FFAR2KIT | |
| Hydrochloric Acid SCHEMBL3938816 | 0.66 | ADRA2A (0.53) | IDH1MKNK1MKNK2FFAR2KIT | |
| SCHEMBL4495992 | 0.65 | NPC1 (0.36) | RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8222261-B2 | Chemical compounds | GlaxoSmithKline, LLC (US) | 2012-07-17 | — | — | US | disclosed |
| US-20090318477-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318477-A1 | CHEMICAL COMPOUNDS | GPR119, GOT2, SLC5A2 | IDH1 804/4885MAP4K4 817/4885MKNK1 1352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.