Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.35 |
| ▸ | CES2 | O00748 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13106440 | 0.95 | TSHR (0.48) | TSHRCES1CYP3A4ADRB2ADRB1 | |
| SCHEMBL28484349 | 0.95 | TSHR (0.48) | TSHRCES1CYP3A4ADRB2ADRB1 | |
| SCHEMBL4494245 | 0.92 | CES1 (0.52) | TSHRCES1MEN1THRBHTT | |
| SCHEMBL534064 | 0.90 | CES1 (0.55) | TSHRCES1MEN1THRBHTT | |
| SCHEMBL4506308 | 0.90 | CES1 (0.55) | TSHRCES1MEN1THRBHTT | |
| SCHEMBL4491457 | 0.90 | CES1 (0.55) | TSHRCES1MEN1THRBHTT | |
| SCHEMBL4483157 | 0.90 | CES1 (0.55) | TSHRCES1MEN1THRBHTT | |
| SCHEMBL4489271 | 0.90 | CES1 (0.55) | TSHRCES1MEN1THRBHTT | |
| SCHEMBL4491774 | 0.90 | CES1 (0.55) | TSHRCES1MEN1THRBHTT | |
| SCHEMBL4488321 | 0.90 | CES1 (0.55) | TSHRCES1MEN1THRBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023171326-A1 | METHOD FOR PRODUCING ALKENE | 株式会社クレハ | 2023-09-14 | — | — | WO | disclosed |
| WO-2023171325-A1 | METHOD FOR PRODUCING ALKENE | 株式会社クレハ | 2023-09-14 | — | — | WO | disclosed |
| US-11708353-B2 | Inhibitors of prolyl-tRNA-synthetase | THE GENERAL HOSPITAL CORPORATION (US) | 2023-07-25 | — | — | US | disclosed |
| US-11186531-B2 | Production method for alkene | KUREHA CORPORATION (JP) | 2021-11-30 | — | — | US | disclosed |
| EP-3831841-A1 | NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF | S&T Global Inc. (US) | 2021-06-09 | — | — | EP | disclosed |
| US-20210047252-A1 | PRODUCTION METHOD FOR ALKENE | KUREHA CORPORATION (JP) | 2021-02-18 | — | — | US | disclosed |
| CN-111712480-A | Process for producing chain olefin | 株式会社吴羽 | 2020-09-25 | — | — | CN | disclosed |
| WO-2019176151-A1 | PRODUCTION METHOD FOR ALKENE | 株式会社クレハ | 2019-09-19 | — | — | WO | disclosed |
| US-20180179242-A1 | CATALYSTS AND METHODS FOR POLYMER SYNTHESIS | NOVOMER, INC. | 2018-06-28 | — | — | US | disclosed |
| US-9951096-B2 | Catalysts and methods for polymer synthesis | SAUDI ARAMCO TECHNOLOGIES COMPANY (SA) | 2018-04-24 | — | — | US | disclosed |
| US-20110152497-A1 | CATALYSTS AND METHODS FOR POLYMER SYNTHESIS | NOVOMER, INC. (US) | 2011-06-23 | — | — | US | disclosed |
| US-20100331348-A1 | TROPANE DERIVATIVES USEFUL AS PESTICIDES | SYNGENTA CROP PROTECTION, INC. (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100168108-A1 | PHENYL DERIVATIVES AND METHODS OF USE | ADOLOR CORPORATION (US) | 2010-07-01 | — | — | US | disclosed |
| US-20100144969-A1 | ISOSELECTIVE POLYMERIZATION OF EPOXIDES | CORNELL UNIVERSITY (US) | 2010-06-10 | — | — | US | disclosed |
| US-7671052-B2 | Phenyl derivatives and methods of use | ADOLOR CORPORATION (US) | 2010-03-02 | — | — | US | disclosed |
| US-20090318513-A1 | COMPOUNDS EXHIBITING THROMBOPOIETIN RECEPTOR AGONISM | SHIONOGI & CO., LTD. | 2009-12-24 | — | — | US | disclosed |
| US-7601746-B2 | Compounds exhibiting thrombopoietin receptor agonism | SHIONOGI & CO., LTD. (JP) | 2009-10-13 | — | — | US | disclosed |
| US-20070043087-A1 | Such as 3-{2,6-difluoro-4-[4,5-dihydro-6-(3,3-dimethylbutyl)naphtho[1,2-d]thiazol-2-ylcabamoyl)phenyl]-2-methylacrylic acid | EDDINGPHARM (HONG KONG) COMPANY LIMITED (CN) | 2007-02-22 | — | — | US | disclosed |
| CN-1863783-A | Compounds with Thrombopoietin Receptor Agonism | SHIONOGI & CO (JP) | 2006-11-15 | — | — | CN | disclosed |
| EP-1655291-A1 | COMPOUNDS HAVING THROMBOPOIETIN RECEPTOR AGONISM | SHIONOGI & CO., LTD. (JP) | 2006-05-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144969-A1 | ISOSELECTIVE POLYMERIZATION OF EPOXIDES | EPHX2, EPHX1, GNE | TSHR 4879/4885CES1 1058/4885CYP3A4 58/4885 |
| US-20090318513-A1 | COMPOUNDS EXHIBITING THROMBOPOIETIN RECEPTOR AGONISM | MPL, TEK, GHRHR | TSHR 9/4885CES1 1766/4885CYP3A4 1949/4885 |
| US-20210047252-A1 | PRODUCTION METHOD FOR ALKENE | ALK, ALKBH3, ALKBH1 | TSHR 3005/4885CES1 352/4885CYP3A4 113/4885 |
| US-11708353-B2 | Inhibitors of prolyl-tRNA-synthetase | GARS1, AARS1, NSUN3 | TSHR 2024/4885CES1 633/4885CYP3A4 3510/4885 |
| US-20070043087-A1 | Such as 3-{2,6-difluoro-4-[4,5-dihydro-6-(3,3-dimethylbutyl)naphtho[1,2-d]thiazol-2-ylcabamoyl)phenyl]-2-methylacrylic acid | DHFR, NAT1, ACR | TSHR 757/4885CES1 322/4885CYP3A4 659/4885 |
| US-20180179242-A1 | CATALYSTS AND METHODS FOR POLYMER SYNTHESIS | PPOX, COASY, SOD1 | TSHR 4849/4885CES1 1268/4885CYP3A4 174/4885 |
| US-11186531-B2 | Production method for alkene | ALK, ALKBH3, ALKBH1 | TSHR 3005/4885CES1 352/4885CYP3A4 113/4885 |
| US-20100331348-A1 | TROPANE DERIVATIVES USEFUL AS PESTICIDES | DDT, ACHE, TPM3 | TSHR 116/4885CES1 99/4885CYP3A4 170/4885 |
| US-20110152497-A1 | CATALYSTS AND METHODS FOR POLYMER SYNTHESIS | PPOX, COASY, SOD1 | TSHR 4849/4885CES1 1268/4885CYP3A4 174/4885 |
| US-20100168108-A1 | PHENYL DERIVATIVES AND METHODS OF USE | CNR2, CNR1, GPR119 | TSHR 1931/4885CES1 1733/4885CYP3A4 1925/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.