SCHEMBL450052

SCHEMBL450052

c1ccc(CC2SCCS2)cc1

nearest known ligand 0.45

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
GBA1 P04062 1/20 0.42
FAAH O00519 1/20 0.40
POLB P06746 1/20 0.38
CCR3 P51677 1/20 0.38
CALM1 P0DP23 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3090521 0.91 FAAH (0.50) GBA1FAAHPOLBCCR3
SCHEMBL4258936 0.77 KDM4E (0.44)
SCHEMBL2285371 0.75 CALM1 (0.41) GBA1CALM1
SCHEMBL6916462 0.73 GBA1 (0.43) GBA1POLBCCR3CALM1
SCHEMBL9150 0.73 TMEM97 (0.44) GBA1FAAHPOLB
SCHEMBL10956979 0.71 NOS1 (0.37) GBA1
SCHEMBL8998 0.70 FAAH (0.43) GBA1FAAHPOLBCCR3
SCHEMBL10952260 0.70 TP53 (0.39) GBA1CALM1
SCHEMBL28090 0.69 POLB (0.44) GBA1FAAHPOLBCCR3
SCHEMBL228875 0.69 POLB (0.44) GBA1FAAHPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 509 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119118863-A 9-Phenanthreneamide derivative and preparation method and application thereof 安徽中医药大学 2024-12-13 CN claimed
CN-118076647-A Photohardenable composition and method for forming an object in the volume of the photohardenable composition 二次3D股份有限公司 2024-05-24 CN claimed
CN-117645607-A Electroluminescent material and application thereof 北京燕化集联光电技术有限公司 2024-03-05 CN claimed
CN-113861128-A Polymerizable compound and optically anisotropic body 江苏创拓新材料有限公司 2021-12-31 CN claimed
CN-109503547-B Process for preparing benzodithiolane derivatives 江苏师范大学 2021-03-16 CN claimed
US-20210033886-A1 LENS FOR SPECTACLES AND SPECTACLES FUJIFILM CORPORATION (JP) 2021-02-04 US claimed
EP-1852420-B1 Indole compounds for treating respiratory disorders ONO PHARMACEUTICAL CO (JP) 2012-10-17 EP claimed
US-7402580-B2 Fused pyridazine derivative compounds and drugs containing these compounds as the active ingredient ONO PHARMACEUTICAL CO., LTD. (JP) 2008-07-22 US claimed
US-20070117041-A1 Photosensitive coating for enhancing a contrast of a photolithographic exposure INFINEON TECHNOLOGIES AG (DE) 2007-05-24 US claimed
US-12630510-B2 EP2 antagonist ONO PHARMACEUTICAL CO., LTD. (JP) 2026-05-19 US disclosed
EP-4727924-A1 INHIBITORS OF TREK (TWIK RELATED K+ CHANNELS) CHANNEL FUNCTION ONO Pharmaceutical Co., Ltd. (JP) 2026-04-22 EP disclosed
US-12600730-B2 Substituted cyclopenta[c]pyrroles as ABHD6 antagonists ONO PHARMACEUTICAL CO., LTD. (JP) 2026-04-14 US disclosed
US-20260083735-A1 ABHD6 ANTAGONIST ONO PHARMACEUTICAL CO., LTD. (JP) 2026-03-26 US disclosed
EP-4682141-A1 TRICYCLIC COMPOUND ONO Pharmaceutical Co., Ltd. (JP) 2026-01-21 EP disclosed
EP-1306373-A1 3,4-DIHYDROISOQUINOLINE DERIVATIVE COMPOUNDS AND DRUGS CONTAINING THESE COMPOUNDS AS THE ACTIVE INGREDIENT ONO PHARMACEUTICAL CO., LTD. (JP) 2003-05-02 EP disclosed
WO-2002076177-A2 DESIGN AND SYNTHESIS OF OPTIMIZED LIGANDS FOR PPAR BETHESDA PHARMACEUTICALS, INC. (US) 2002-10-03 WO disclosed
EP-1236726-A1 TRIAZASPIRO 5.5]UNDECANE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT ONO PHARMACEUTICAL CO., LTD. (JP) 2002-09-04 EP disclosed
WO-2002066443-A2 2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE DERIVATIVES ONO PHARMACEUTICAL CO., LTD. (JP) 2002-08-29 WO disclosed
US-6369098-B1 PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-.GAMMA. (PPAR.GAMMA.) AND/OR PPAR.ALPHA TREATMENT OF ENDOCRINE, SKIN, CARDIOVASCULAR, IMMUNOLOGICAL, NEUROLOGICAL, NEUROPSYCHIATRIC, NEOPLASTIC AND CHRONIC VIRAL DISEASES OF VARIOUS ORGANS BETHESDA PHARMACEUTICALS, INC. 2002-04-09 US disclosed
WO-2001025226-A1 DITHIOLANE DERIVATIVES BETHESDA PHARMACEUTICALS, INC. (US) 2001-04-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12630510-B2 EP2 antagonist PTGER2, PTGER1, PTGER4 GBA1 2136/4885FAAH 660/4885POLB 4248/4885
US-12600730-B2 Substituted cyclopenta[c]pyrroles as ABHD6 antagonists ABHD6, ABHD16A, HDHD5 GBA1 292/4885FAAH 138/4885POLB 1870/4885
US-20260083735-A1 ABHD6 ANTAGONIST ABHD6, ABHD16A, ABHD12 GBA1 494/4885FAAH 352/4885POLB 3296/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.