SCHEMBL452239

SCHEMBL452239

[C]1[C]Nc2ccccc2C1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.35
NPC1 O15118 2/20 0.34
AHR P35869 1/20 0.34
PDK2 Q15119 1/20 0.34
KDM4E B2RXH2 1/20 0.34
MEN1 O00255 1/20 0.34
HSP90AA1 P07900 1/20 0.34
THRB P10828 1/20 0.34
HK1 P19367 1/20 0.34
MAPK1 P28482 1/20 0.34
RECQL P46063 1/20 0.34
RAB9A P51151 1/20 0.34
GALK1 P51570 1/20 0.34
BLM P54132 1/20 0.34
KMT2A Q03164 1/20 0.34
HKDC1 Q2TB90 1/20 0.34
ALOX15 P16050 1/20 0.34
HSD17B10 Q99714 1/20 0.34
PLAU P00749 1/20 0.33
MAPK13 O15264 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13279465 0.78 MAPT (0.41) MAPTNPC1AHRPDK2KDM4E
SCHEMBL19678 0.76
SCHEMBL8685779 0.74 MAPT (0.35) MAPTNPC1AHRPDK2KDM4E
SCHEMBL3937255 0.72 CHRNB2 (0.38)
SCHEMBL1162905 0.68 TSHR (0.42) HTR2C
SCHEMBL3939166 0.67 ADRA2A (0.32)
SCHEMBL2655668 0.64 PLAU (0.42) MAPTNPC1AHRPDK2KDM4E
SCHEMBL429453 0.64 ALOX15 (0.43) MAPTNPC1AHRPDK2KDM4E
SCHEMBL447750 0.64 NPC1 (0.34) MAPTNPC1AHRPDK2KDM4E
SCHEMBL209284 0.64 NPC1 (0.34) MAPTNPC1AHRPDK2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 167 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2697232-B1 6,7-DIHYDROIMIDAZO[2,1-B][1,3]OXAZINE BACTERICIDES OTSUKA PHARMA CO LTD (JP) 2016-05-18 EP claimed
US-9051333-B2 6,7-dihydroimidazo [2,1-b] [1,3]oxazine bactericides OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2015-06-09 US claimed
US-20140031342-A1 6,7-DIHYDROIMIDAZO [2,1-b] [1,3]OXAZINE BACTERICIDES OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2014-01-30 US claimed
CN-118076602-A Heteroaryl-acetylenes, pharmaceutical compositions thereof and their therapeutic uses 嘉兴优博生物技术有限公司 2024-05-24 CN disclosed
EP-3010943-B1 CURABLE COMPOSITION, FILM, AND METHOD OF PRODUCING FILM CANON KK (JP) 2024-04-03 EP disclosed
EP-4316850-A1 ELECTRON BEAM CURING INKJET INK, INK SET, AND IMAGE RECORDING METHOD FUJIFILM Corporation (JP) 2024-02-07 EP disclosed
US-11890288-B2 Sulfonamide or sulfinamide compound having effect of inducing BRD4 protein degradation and pharmaceutical use thereof MITSUBISHI TANABE PHARMA CORPORATION (JP) 2024-02-06 US disclosed
US-20240018374-A1 INK JET INK FOR ELECTRON BEAM CURING, INK SET, AND IMAGE RECORDING METHOD FUJIFILM CORPORATION (JP) 2024-01-18 US disclosed
CN-117203196-A PDE4 degrading agents, pharmaceutical compositions and therapeutic applications 拜欧斯瑞克斯公司 2023-12-08 CN disclosed
EP-4286163-A1 ELECTRON BEAM-CURABLE INK, AND IMAGE RECORDING METHOD FUJIFILM Corporation (JP) 2023-12-06 EP disclosed
US-20230364105-A1 SULFONAMIDE OR SULFINAMIDE COMPOUND HAVING EFFECT OF INDUCING BRD4 PROTEIN DEGRADATION AND PHARMACEUTICAL USE THEREOF MITSUBISHI TANABE PHARMA CORPORATION (JP) 2023-11-16 US disclosed
US-20070004823-A1 Ink composition, image forming method and printed article FUJI PHOTO FILM CO., LTD. 2007-01-04 US disclosed
EP-1739141-A1 Ink composition, image forming method and printed article Fuji Photo Film Co., Ltd. (JP) 2007-01-03 EP disclosed
US-20060194029-A1 Ink composition, inkjet recording method using the same, and printed material FUJI PHOTO FILM CO., LTD. 2006-08-31 US disclosed
US-20050038035-A1 Heterocyclic amide compounds as apolipoprotein b inhibitors DAISO CO., LTD. (JP) 2005-02-17 US disclosed
EP-1472226-A1 HETEROCYCLIC AMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-11-03 EP disclosed
US-20040209913-A1 e.g., 3-[1-(3,5-Dichloroisonicotinoyl)-2,3-dihydro-1 H-indol-5-yl]-2-[(3-oxo-spiro[3.5]non-1-en-1-yl)amino]-propanoate; modulating cell adhesion for the prophylaxis or treatment of inflammatory diseases or disorders, such as rheumatoid arthritis, in which the extravasculation of leukocytes plays a role. UCB PHARMA S.A. (BE) 2004-10-21 US disclosed
US-20040133008-A1 Amide compounds FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-07-08 US disclosed
WO-2004039795-A2 AMIDE COMPOUNDS FOR THE TREATMENT OF HYPERLIPIDEMIA FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-05-13 WO disclosed
WO-2003045921-A1 HETEROCYCLIC AMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2003-06-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11890288-B2 Sulfonamide or sulfinamide compound having effect of inducing BRD4 protein degradation and pharmaceutical use thereof BRD4, BRD1, BRD2 MAPT 2004/4885NPC1 3907/4885AHR 1870/4885
US-20230364105-A1 SULFONAMIDE OR SULFINAMIDE COMPOUND HAVING EFFECT OF INDUCING BRD4 PROTEIN DEGRADATION AND PHARMACEUTICAL USE THEREOF BRD4, BRD1, BRD2 MAPT 2004/4885NPC1 3907/4885AHR 1870/4885
US-20040133008-A1 Amide compounds APOB, APOL1, LDLR MAPT 4101/4885NPC1 34/4885AHR 55/4885
US-20140031342-A1 6,7-DIHYDROIMIDAZO [2,1-b] [1,3]OXAZINE BACTERICIDES BRD1, OXA1L, QDPR MAPT 3136/4885NPC1 3212/4885AHR 546/4885
US-20050038035-A1 Heterocyclic amide compounds as apolipoprotein b inhibitors APOB, APOL1, CTRB2 MAPT 4202/4885NPC1 100/4885AHR 56/4885
US-20040209913-A1 e.g., 3-[1-(3,5-Dichloroisonicotinoyl)-2,3-dihydro-1 H-indol-5-yl]-2-[(3-oxo-spiro[3.5]non-1-en-1-yl)amino]-propanoate; modulating cell adhesion for the prophylaxis or treatment of inflammatory diseases or disorders, such as rheumatoid arthritis, in which the extravasculation of leukocytes plays a role. ICAM1, VCAM1, CCR1 MAPT 4346/4885NPC1 2595/4885AHR 179/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.