Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 1/20 | 0.56 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.53 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.53 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.53 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.53 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.53 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.53 |
| ▸ | DRD2 | P14416 | 2/20 | 0.50 |
| ▸ | DRD4 | P21917 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537477 | 0.90 | NCOA1 (0.53) | PAX8RAB9A | |
| SCHEMBL4537510 | 0.90 | RAB9A (0.56) | PAX8RAB9AHTR7LMNAALDH1A1 | |
| SCHEMBL4542333 | 0.90 | PSEN1 (0.51) | PAX8PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4538787 | 0.90 | PSEN1 (0.51) | PAX8PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4542139 | 0.89 | PAX8 (0.45) | PAX8DRD2DRD4RAB9AHTR7 | |
| SCHEMBL4536836 | 0.87 | BRD4 (0.55) | PAX8RAB9AALDH1A1 | |
| SCHEMBL4535933 | 0.87 | PSEN1 (0.56) | PAX8PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4531591 | 0.84 | DRD2 (0.42) | DRD2DRD4 | |
| SCHEMBL4535463 | 0.83 | HTR7 (0.55) | DRD2RAB9AHTR7NPSR1 | |
| SCHEMBL4537553 | 0.82 | PAX8 (0.58) | PAX8PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |