Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCOA1 | Q15788 | 1/20 | 0.53 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.48 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537550 | 0.90 | PAX8 (0.56) | RAB9APAX8 | |
| SCHEMBL4537510 | 0.90 | RAB9A (0.56) | NCOA1NCOA3RAB9APAX8NPC1 | |
| SCHEMBL4541154 | 0.90 | RAB9A (0.56) | RAB9APAX8 | |
| SCHEMBL4535463 | 0.89 | HTR7 (0.55) | NCOA1NCOA3RAB9ANPC1 | |
| SCHEMBL4536836 | 0.87 | BRD4 (0.55) | NCOA1NCOA3RAB9APAX8NPC1 | |
| SCHEMBL4535257 | 0.87 | RAB9A (0.53) | NCOA1NCOA3RAB9APAX8GAA | |
| SCHEMBL4542139 | 0.83 | PAX8 (0.45) | RAB9APAX8NPC1 | |
| SCHEMBL4537480 | 0.82 | NCOA1 (0.54) | NCOA1NCOA3RAB9APAX8FKBP1A | |
| SCHEMBL4539521 | 0.81 | ALDH1A1 (0.46) | GAA | |
| SCHEMBL4531591 | 0.80 | DRD2 (0.42) | HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |