Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.32 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.31 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.31 |
| ▸ | ANPEP | P15144 | 3/20 | 0.31 |
| ▸ | LAP3 | P28838 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7627856 | 0.95 | CES2 (0.35) | ALDH1A1TDP1CES2LPAR1LPAR3 | |
| SCHEMBL8630560 | 0.91 | GRIN2D (0.33) | TDP1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8410344 | 0.86 | ALDH1A1 (0.31) | ALDH1A1TDP1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL10994878 | 0.84 | MEN1 (0.34) | ALDH1A1TDP1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL3001830 | 0.81 | CES2 (0.44) | MEN1KMT2ACES2LPAR1LPAR3 | |
| SCHEMBL8410340 | 0.81 | — | — | |
| SCHEMBL8414151 | 0.81 | GRIN2D (0.31) | TDP1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL963978 | 0.80 | ACACB (0.34) | ALDH1A1TDP1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL7625718 | 0.79 | CES2 (0.55) | MEN1KMT2ACES2LPAR1LPAR3 | |
| SCHEMBL11383173 | 0.78 | LPAR1 (0.36) | MEN1KMT2ACES2LPAR1LPAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7928252-B2 | Prostaglandin synthesis and intermediates for use therein | ALPHORA RESEARCH INC. (CA) | 2011-04-19 | — | — | US | claimed |
| US-20100056808-A1 | PROSTAGLANDIN SYNTHESIS AND INTERMEDIATES FOR USE THEREIN | ALPHORA RESEARCH INC. (CA) | 2010-03-04 | — | — | US | claimed |
| US-20100056807-A1 | PROSTAGLANDIN SYNTHESIS AND INTERMEDIATES FOR USE THEREIN | ALPHORA RESEARCH INC. (CA) | 2010-03-04 | — | — | US | claimed |
| EP-1981867-B1 | METHOD FOR PREPARING PROSTAGLANDIN DERIVATIVE | R-TECH UENO LTD (JP) | 2017-06-14 | — | — | EP | disclosed |
| US-9382272-B2 | Methods of making lubiprostone and intermediates thereof | APOTEX PHARMACHEM INC. (CA) | 2016-07-05 | — | — | US | disclosed |
| US-8785663-B2 | Polymorphic forms of Lubiprostone | APOTEX PHARMACHEM INC. (CA) | 2014-07-22 | — | — | US | disclosed |
| EP-2735566-A1 | Method for preparing prostaglandin derivative | R-Tech Ueno, Ltd. (JP) | 2014-05-28 | — | — | EP | disclosed |
| US-20130338379-A1 | PROSTAGLANDIN SYNTHESIS AND INTERMEDIATES FOR USE THEREIN | ALPHORA RESEARCH INC. (CA) | 2013-12-19 | — | — | US | disclosed |
| US-8513441-B2 | Prostaglandin synthesis and intermediates for use therein | ALPHORA RESEARCH INC. (CA) | 2013-08-20 | — | — | US | disclosed |
| US-20130096325-A1 | POLYMORPHIC FORMS OF LUBIPROSTONE | APOTEX PHARMACHEM INC. (CA) | 2013-04-18 | — | — | US | disclosed |
| US-20130072695-A1 | PROSTAGLANDIN SYNTHESIS AND INTERMEDIATES FOR USE THEREIN | ALPHORA RESEARCH INC. (CA) | 2013-03-21 | — | — | US | disclosed |
| US-5107014-A | Prostaglandin I analogue | K.K. UENO SEIYAKU OYO KENKYUJO (JP) | 1992-04-21 | — | — | US | disclosed |
| EP-0469782-A2 | Treatment of cataract with prostacyclin compounds | KABUSHIKI KAISHA UENO SEIYAKU OYO KENKYUJO (JP) | 1992-02-05 | — | — | EP | disclosed |
| EP-0455899-A1 | Prostaglandin I analogue | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo (JP) | 1991-11-13 | — | — | EP | disclosed |
| EP-0284180-A1 | Prostaglandins E and anti ulcers containing same | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo (JP) | 1988-09-28 | — | — | EP | disclosed |
| US-4256911-A | TRIFLUOROMETHYL-CARBOXY ESTERS | HOFFMANN-LA ROCHE INC. (US) | 1981-03-17 | — | — | US | disclosed |
| US-4237276-A | CARDIOVASCULAR AGENTS, INDUCTION OF LABOR, TERMINATION OF PREGNANCY | HOFFMANN-LA ROCHE INC. (US) | 1980-12-02 | — | — | US | disclosed |
| US-4211724-A | ENANTIOMORPHS, INTERMEDIATE AMIDES WITH ASSYMETRIC CARBON ATOM | HOFFMAN-LA ROCHE INC. (US) | 1980-07-08 | — | — | US | disclosed |
| US-4187381-A | CARDIOVASCULAR AGENTS; OXYTOCICS | HOFFMANN-LA ROCHE INC. (US) | 1980-02-05 | — | — | US | disclosed |
| US-4001300-A | ANTIULCER, DECONGESTANT, LABOR INDUCER, WOUND HEALER | THE UPJOHN COMPANY (US) | 1977-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130096325-A1 | POLYMORPHIC FORMS OF LUBIPROSTONE | APOB, OSBP2, LDLR | ALDH1A1 3210/4885TDP1 2561/4885GRIN2D 4438/4885 |
| US-20130072695-A1 | PROSTAGLANDIN SYNTHESIS AND INTERMEDIATES FOR USE THEREIN | ALOX5, PTGES, PTGIS | ALDH1A1 914/4885TDP1 4742/4885GRIN2D 4145/4885 |
| US-20130338379-A1 | PROSTAGLANDIN SYNTHESIS AND INTERMEDIATES FOR USE THEREIN | ALOX5, PTGES, PTGIS | ALDH1A1 914/4885TDP1 4742/4885GRIN2D 4145/4885 |
| US-20100056807-A1 | PROSTAGLANDIN SYNTHESIS AND INTERMEDIATES FOR USE THEREIN | ALOX5, PTGES, PTGIS | ALDH1A1 914/4885TDP1 4742/4885GRIN2D 4145/4885 |
| US-20100056808-A1 | PROSTAGLANDIN SYNTHESIS AND INTERMEDIATES FOR USE THEREIN | ALOX5, PTGES, ALOX15 | ALDH1A1 1139/4885TDP1 4761/4885GRIN2D 4223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.