Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | THRA | P10827 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | VDR | P11473 | 1/20 | 0.33 |
| ▸ | USP5 | P45974 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | NPY2R | P49146 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13586356 | 0.92 | PTPN2 (0.41) | GPR119SMN1; SMN2HTR1AMEN1KMT2A | |
| SCHEMBL4352059 | 0.90 | P2RY12 (0.41) | GPR119SMN1; SMN2KDM4E | |
| SCHEMBL4538002 | 0.89 | NPY2R (0.42) | GPR119SMN1; SMN2KCNH2HRH3HTR1A | |
| SCHEMBL4352809 | 0.88 | GPR119 (0.46) | GPR119KDM4EKMT2A | |
| SCHEMBL4538200 | 0.87 | POLB (0.42) | SMN1; SMN2HRH3CD274KDM4EMEN1 | |
| SCHEMBL4533473 | 0.86 | LMNA (0.40) | SLC6A4CD274NAMPT | |
| SCHEMBL4534161 | 0.86 | SCD5 (0.41) | GPR119SMN1; SMN2KCNH2HRH3NPY2R | |
| SCHEMBL4540129 | 0.86 | ALDH1A1 (0.43) | SMN1; SMN2CD274NAMPTMEN1KMT2A | |
| SCHEMBL4350134 | 0.85 | CD274 (0.36) | HRH3SLC6A4CD274KDM4ENAMPT | |
| SCHEMBL4360517 | 0.85 | NAMPT (0.41) | GPR119CD274NPY2RNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009150144-A1 | NEW GPR119MODULATORS | INOVACIA AB (SE) | 2009-12-17 | — | — | WO | disclosed |