SCHEMBL4547745

SCHEMBL4547745

CC(=O)Nc1ccc(F)c(B(O)O)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.49
KMT2A Q03164 4/20 0.49
MAPT P10636 3/20 0.49
ALDH1A1 P00352 3/20 0.49
SMN1; SMN2 Q16637 3/20 0.47
PREP P48147 1/20 0.47
HTT P42858 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
KDM4E B2RXH2 1/20 0.46
NPC1 O15118 1/20 0.46
GLA P06280 1/20 0.46
TNNI3 P19429 1/20 0.46
TNNT2 P45379 1/20 0.46
RAB9A P51151 1/20 0.46
TNNC1 P63316 1/20 0.46
RUNX1 Q01196 1/20 0.46
CBFB Q13951 1/20 0.46
POLB P06746 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
CA12 O43570 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30368269 0.81 RAB9A (0.58) MEN1KMT2AMAPTALDH1A1SMN1; SMN2
SCHEMBL863069 0.81 RAB9A (0.58) MEN1KMT2AMAPTALDH1A1SMN1; SMN2
SCHEMBL1369735 0.80 TGM2 (0.56)
SCHEMBL3323005 0.80 SMN1; SMN2 (0.54) MEN1KMT2AMAPTALDH1A1SMN1; SMN2
SCHEMBL3788150 0.80 HTT (0.48) MEN1KMT2AMAPTALDH1A1SMN1; SMN2
SCHEMBL1889302 0.80 PKM (0.53) MEN1KMT2AMAPTALDH1A1SMN1; SMN2
SCHEMBL4547744 0.79 LMNA (0.46) MEN1KMT2AMAPTALDH1A1SMN1; SMN2
SCHEMBL8873149 0.79 ALDH1A1 (0.51) MEN1KMT2AMAPTALDH1A1SMN1; SMN2
SCHEMBL13414534 0.78 ALDH1A1 (0.53) MEN1KMT2AMAPTALDH1A1SMN1; SMN2
SCHEMBL11802375 0.78 PKM (0.59) MEN1KMT2AMAPTALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1601999-B1 Holographic sensor and its use SMART HOLOGRAMS LTD (GB) 2013-04-24 EP disclosed
US-8241574-B2 Ophthalmic device comprising a holographic sensor SMART HOLOGRAMS LIMITED (GB) 2012-08-14 US disclosed
US-8241574-B2 Ophthalmic device comprising a holographic sensor SMART HOLOGRAMS LIMITED (GB) 2012-08-14 US disclosed
US-20120107944-A1 Holographic Sensor LOWE CHRISTOPHER ROBIN (GB) 2012-05-03 US disclosed
US-20120107944-A1 Holographic Sensor LOWE CHRISTOPHER ROBIN (GB) 2012-05-03 US disclosed
US-20110286064-A1 OPHTHALMIC DEVICE COMPRISING A HOLOGRAPHIC SENSOR BURLES BARRY (GB) 2011-11-24 US disclosed
US-20110286064-A1 OPHTHALMIC DEVICE COMPRISING A HOLOGRAPHIC SENSOR BURLES BARRY (GB) 2011-11-24 US disclosed
US-8048680-B2 Holographic sensor SMART HOLOGRAMS LIMITED (GB) 2011-11-01 US disclosed
US-8048680-B2 Holographic sensor SMART HOLOGRAMS LIMITED (GB) 2011-11-01 US disclosed
US-7998412-B2 Ophthalmic device comprising a holographic sensor SMART HOLOGRAMS LIMITED (GB) 2011-08-16 US disclosed
US-7998412-B2 Ophthalmic device comprising a holographic sensor SMART HOLOGRAMS LIMITED (GB) 2011-08-16 US disclosed
US-20090021697-A1 Ophthalmic Device Comprising a Holographic Sensor SMART HOLOGRAMS LIMITED (GB) 2009-01-22 US disclosed