Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3242097 | 0.94 | KDM4E (0.35) | LMNATDP1KDM4EALDH1A1MAPT | |
| SCHEMBL857034 | 0.90 | PTPN1 (0.33) | LMNATDP1 | |
| SCHEMBL3239940 | 0.87 | KDM4E (0.31) | KDM4EALDH1A1MAPTTHRBRECQL | |
| SCHEMBL1797106 | 0.87 | LMNA (0.39) | LMNATDP1KDM4EMAPTTHRB | |
| SCHEMBL31166034 | 0.87 | MAPT (0.41) | LMNATDP1KDM4EALDH1A1MAPT | |
| Potassium Ion SCHEMBL7745644 | 0.84 | MAPT (0.41) | LMNATDP1KDM4EALDH1A1MAPT | |
| Potassium Ion SCHEMBL30656252 | 0.84 | MAPT (0.41) | LMNATDP1KDM4EALDH1A1MAPT | |
| SCHEMBL6301516 | 0.84 | L3MBTL1 (0.33) | TDP1KDM4EALDH1A1MAPT | |
| SCHEMBL3242102 | 0.84 | LMNA (0.31) | LMNATDP1 | |
| SCHEMBL137086 | 0.84 | LMNA (0.31) | LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588541-A1 | DYE COMPOSITIONS AND DYE SYNTHESES | GE Healthcare AS (NO) | 2013-05-08 | — | — | EP | disclosed |
| US-20130095040-A1 | DYE COMPOSITIONS AND DYE SYNTHESES | GE HEALTHCARE AS (NO) | 2013-04-18 | — | — | US | disclosed |
| US-8148539-B2 | Cyanine dye labelling reagents | GE HEALTHCARE UK LIMITED (GB) | 2012-04-03 | — | — | US | disclosed |
| WO-2012001063-A1 | DYE COMPOSITIONS AND DYE SYNTHESES | GE HEALTHCARE AS (NO) | 2012-01-05 | — | — | WO | disclosed |
| EP-1678258-B1 | CYANINE DYE LABELLING REAGENTS | GE HEALTHCARE LTD (GB) | 2011-08-31 | — | — | EP | disclosed |
| EP-2360211-A1 | Fluorescently-labelled target components | GE Healthcare Limited (GB) | 2011-08-24 | — | — | EP | disclosed |
| US-20100267937-A1 | Cyanine Dye Labelling Reagents | WEST RICHARD M | 2010-10-21 | — | — | US | disclosed |
| US-7750163-B2 | Cyanine dye labelling reagents | GE Healthcare U.K. Limited (GB) | 2010-07-06 | — | — | US | disclosed |
| US-20070203343-A1 | Cyanine Dye Labelling Reagents | GE HEALTHCARE UK LIMITED (GB) | 2007-08-30 | — | — | US | disclosed |
| EP-1678258-A1 | CYANINE DYE LABELLING REAGENTS | GE Healthcare Limited (GB) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005044923-A1 | CYANINE DYE LABELLING REAGENTS | GE HEALTHCARE LIMITED (GB) | 2005-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203343-A1 | Cyanine Dye Labelling Reagents | IK, H1-5, H1-3 | THRB 2655/4885LMNA 2011/4885TDP1 2545/4885 |
| US-20100267937-A1 | Cyanine Dye Labelling Reagents | IK, H1-5, H1-3 | THRB 2642/4885LMNA 1861/4885TDP1 2249/4885 |
| US-20130095040-A1 | DYE COMPOSITIONS AND DYE SYNTHESES | CD47, CD99, CD68 | THRB 4332/4885LMNA 3726/4885TDP1 4412/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.