Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4558558 | 1.00 | ALOX15 (0.40) | ALOX15CYP3A4KDM4EMEN1TSHR | |
| SCHEMBL15370117 | 0.72 | CYP3A4 (0.31) | ALOX15CYP3A4 | |
| SCHEMBL11295202 | 0.72 | CYP3A4 (0.31) | ALOX15CYP3A4 | |
| SCHEMBL11295201 | 0.72 | CYP3A4 (0.31) | ALOX15CYP3A4 | |
| SCHEMBL6026437 | 0.70 | ALDH1A1 (0.32) | KDM4E | |
| SCHEMBL11319387 | 0.70 | — | — | |
| SCHEMBL517340 | 0.65 | — | — | |
| SCHEMBL517338 | 0.65 | — | — | |
| SCHEMBL16920998 | 0.63 | ALOX15 (0.43) | ALOX15CYP3A4KDM4EMEN1TSHR | |
| SCHEMBL1374556 | 0.63 | ALOX15 (0.74) | ALOX15CYP3A4KDM4EMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10273202-B2 | Nitroxyl progenitor compounds and methods of use | THE JOHNS HOPKINS UNIVERSITY (US) | 2019-04-30 | — | — | US | disclosed |
| US-20090281067-A1 | Nitroxyl progenitor compounds and methods of use | THE JOHN HOPKINS UNIVERSITY (US) | 2009-11-12 | — | — | US | disclosed |
| US-7122529-B2 | Compounds that release nitric oxide at controlled rates upon photolysis | THE JOHNS HOPKINS UNIVERSITY (US) | 2006-10-17 | — | — | US | disclosed |
| US-20040158048-A1 | Compounds that release nitric oxide at controlled rates upon photolysis | THE JOHNS HOPKINS UNIVERSITY | 2004-08-12 | — | — | US | disclosed |
| WO-2003006427-A1 | COMPOUNDS THAT RELEASE NITRIC OXIDE AT CONTROLLED RATES UPON PHOTOLYSIS | JOHNS HOPKINS UNIVERSITY (US) | 2003-01-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040158048-A1 | Compounds that release nitric oxide at controlled rates upon photolysis | NOS2, NOS1, NOS3 | ALOX15 474/4885CYP3A4 120/4885KDM4E 1792/4885 |
| US-20090281067-A1 | Nitroxyl progenitor compounds and methods of use | HMOX2, NNMT, HMOX1 | ALOX15 133/4885CYP3A4 1820/4885KDM4E 1501/4885 |
| US-10273202-B2 | Nitroxyl progenitor compounds and methods of use | HMOX2, NNMT, HMOX1 | ALOX15 133/4885CYP3A4 1820/4885KDM4E 1501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.