Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 8/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | UBE2M | P61081 | 1/20 | 0.38 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.38 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4586335 | 0.90 | CCR5 (0.53) | CCR5CHRM2CHRM3UBE2MDCUN1D1 | |
| SCHEMBL4586726 | 0.89 | CCR5 (0.46) | CCR5CHRM2CHRM3UBE2MDCUN1D1 | |
| SCHEMBL4586071 | 0.87 | KCNH2 (0.52) | CCR5DCUN1D1KCNJ1KCNH2 | |
| SCHEMBL4242144 | 0.84 | UBE2M (0.43) | CCR5UBE2MDCUN1D1 | |
| SCHEMBL4247149 | 0.80 | UBE2M (0.42) | CCR5OPRM1CHRM2CHRM3UBE2M | |
| SCHEMBL4244706 | 0.76 | GPR119 (0.50) | — | |
| SCHEMBL4586432 | 0.75 | CCR5 (0.54) | CCR5 | |
| SCHEMBL4586423 | 0.75 | CCR5 (0.41) | CCR5OPRM1TMEM97 | |
| SCHEMBL4586731 | 0.73 | OPRM1 (0.53) | CCR5OPRM1CHRM2CHRM3 | |
| SCHEMBL4243399 | 0.73 | CCR5 (0.53) | CCR5UBE2MDCUN1D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1708703-A4 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC (CA) | 2008-04-09 | — | — | EP | disclosed |
| EP-1708703-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC. (CA) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005059107-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC. (CA) | 2005-06-30 | — | — | WO | disclosed |