Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 3/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 2/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5722345 | 1.00 | L3MBTL1 (0.36) | L3MBTL1MAPTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL21211664 | 0.85 | GAA (0.39) | ALDH1A1KDM4ELMNAGAAACHE | |
| SCHEMBL22562822 | 0.82 | CYP1A2 (0.34) | CYP1A2HCAR3ACHEPDE4AADORA2A | |
| SCHEMBL29445748 | 0.79 | NR1H2 (0.32) | NR1H2 | |
| SCHEMBL30269815 | 0.79 | NR1H2 (0.32) | NR1H2 | |
| SCHEMBL22643976 | 0.74 | GRIA1 (0.40) | L3MBTL1MAPTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL30269819 | 0.73 | NR1H2 (0.31) | NR1H2 | |
| SCHEMBL21943143 | 0.68 | ALDH1A1 (0.58) | MAPTALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL30291852 | 0.68 | MMP9 (0.33) | L3MBTL1ALDH1A1HTTMEN1CYP1A2 | |
| SCHEMBL13349255 | 0.67 | MEN1 (0.33) | L3MBTL1MAPTALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0631578-A1 | ITRACONAZOLE AND SAPERCONAZOLE STEREOISOMERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-01-04 | — | — | EP | claimed |
| WO-1993019061-A1 | ITRACONAZOLE AND SAPERCONAZOLE STEREOISOMERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-09-30 | — | — | WO | claimed |
| CN-118512393-A | Itraconazole oral liquid and preparation method thereof | 无锡富泽药业有限公司 | 2024-08-20 | — | — | CN | disclosed |
| CN-114767636-B | Itraconazole pellets, preparation method and itraconazole pellet capsule | 苏州中化药品工业有限公司 | 2023-11-07 | — | — | CN | disclosed |
| CN-114767684-B | Pharmaceutical composition, itraconazole pellets, preparation method and itraconazole capsules | 苏州中化药品工业有限公司 | 2023-10-27 | — | — | CN | disclosed |
| CN-109970669-B | Preparation method of intermediate compound of itraconazole | 上海医药工业研究院 | 2022-10-28 | — | — | CN | disclosed |
| CN-114767636-A | Itraconazole pellet, preparation method and itraconazole pellet capsule | 苏州中化药品工业有限公司 | 2022-07-22 | — | — | CN | disclosed |
| CN-114767684-A | Pharmaceutical composition, itraconazole pellet, preparation method and itraconazole capsule | 苏州中化药品工业有限公司 | 2022-07-22 | — | — | CN | disclosed |
| US-11369601-B2 | Prophylactic or therapeutic agent for pulmonary hypertension comprising mebendazole and/or itraconazole or salt thereof | TOHOKU UNIVERSITY (JP) | 2022-06-28 | — | — | US | disclosed |
| US-11028078-B2 | Itraconazole analogs and use thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2021-06-08 | — | — | US | disclosed |
| US-20190040046-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-02-07 | — | — | US | disclosed |
| US-9839636-B2 | Itraconazole analogues and methods of use thereof | UNIVERSITY OF CONNECTICUT (US) | 2017-12-12 | — | — | US | disclosed |
| US-9724418-B2 | Drug combinations comprising a DGAT inhibitor and a PPAR-agonist | JANSSEN PHARMACEUTICA NV (BE) | 2017-08-08 | — | — | US | disclosed |
| US-9688696-B2 | Piperidine/piperazine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2017-06-27 | — | — | US | disclosed |
| US-20170029440-A1 | PIPERIDINE/PIPERAZINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2017-02-02 | — | — | US | disclosed |
| EP-1718640-A4 | NOVEL CRYSTALLINE FORMS OF CONAZOLES AND METHODS OF MAKING AND USING THE SAME | TRANSFORM PHARMACEUTICALS INC (US) | 2008-01-09 | — | — | EP | disclosed |
| EP-1718640-A1 | NOVEL CRYSTALLINE FORMS OF CONAZOLES AND METHODS OF MAKING AND USING THE SAME | Transform Pharmaceuticals, Inc. (US) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005092884-A1 | NOVEL CRYSTALLINE FORMS OF CONAZOLES AND METHODS OF MAKING AND USING THE SAME | TRANSFORM PHARMACEUTICALS, INC. (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2004050068-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING A BASIC RESPECTIVELY ACIDIC DRUG COMPOUND, A SURFACTANT AND A PHYSIOLOGICALLY TOLERABLE WATER-SOLUBLE ACID RESPECTIVELY BASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-06-17 | — | — | WO | disclosed |
| EP-0283992-A2 | 4-[4-[4-[4-[[2-(2,4-Difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]-methoxy]phenyl]-1-piperazinyl]phenyl]triazolones | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-09-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170029440-A1 | PIPERIDINE/PIPERAZINE DERIVATIVES | DGAT1, PAOX, DGAT2 | L3MBTL1 2489/4885MAPT 2270/4885ALDH1A1 590/4885 |
| US-20190040046-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | SHH, GLI1, KDR | L3MBTL1 3546/4885MAPT 3556/4885ALDH1A1 1448/4885 |
| US-11028078-B2 | Itraconazole analogs and use thereof | SHH, GLI1, KDR | L3MBTL1 3546/4885MAPT 3556/4885ALDH1A1 1448/4885 |
| US-11369601-B2 | Prophylactic or therapeutic agent for pulmonary hypertension comprising mebendazole and/or itraconazole or salt thereof | ERG28, NHERF1, REN | L3MBTL1 4320/4885MAPT 4066/4885ALDH1A1 2052/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.