Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Medronic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.56 |
| ▸ | TYMS known ✓ | P04818 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | MMP2 | P08253 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.41 |
| ▸ | OTC | P00480 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | BTN3A1 | O00481 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | PGK1 | P00558 | 1/20 | 0.32 |
| ▸ | PGK2 | P07205 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Medronic Acid SCHEMBL27363301 | 0.97 | KDM4E (0.53) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL2638879 | 0.80 | SLC34A1 (0.41) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL9457334 | 0.79 | KDM4E (0.48) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL409013 | 0.78 | LMNA (0.35) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL5272656 | 0.74 | LMNA (0.33) | SLC34A1LMNABTN3A1 | |
| Medronic Acid SCHEMBL66716 | 0.73 | — | — | |
| Medronic Acid SCHEMBL8350837 | 0.73 | KDM4E (1.00) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL7929832 | 0.73 | SLC34A1 (0.50) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL133343 | 0.72 | SLC34A1 (0.47) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL5267588 | 0.70 | SLC34A1 (0.43) | KDM4EMMP2THRBMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11674162-B2 | Selective advantage in fermentation | GINKGO BIOWORKS, INC. (US) | 2023-06-13 | — | — | US | disclosed |
| CN-113631225-A | Methods and systems for producing AAV particles | 沃雅戈治疗公司 | 2021-11-09 | — | — | CN | disclosed |
| CN-103271083-B | Multi-functional ionic liquid compositions | 阿拉巴马大学 | 2017-08-11 | — | — | CN | disclosed |
| US-20170096691-A1 | SELECTIVE ADVANTAGE IN FERMENTATION | NOVOGY, INC. (US) | 2017-04-06 | — | — | US | disclosed |
| WO-2015168534-A1 | THERAPEUTIC TREATMENT OF GASTROINTESTINAL MICROBIAL IMBALANCES THROUGH COMPETITIVE MICROBE DISPLACEMENT | NOVOGY, INC. (US) | 2015-11-05 | — | — | WO | disclosed |
| EP-1328616-B2 | STABILIZED LIQUID COMPOSITIONS | PROCTER & GAMBLE (US) | 2015-03-04 | — | — | EP | disclosed |
| EP-1978081-B1 | Stabilized liquid compositions | PROCTER & GAMBLE (US) | 2014-04-30 | — | — | EP | disclosed |
| CN-103271083-A | Multi-functional ionic liquid compositions | UNIV ALABAMA | 2013-09-04 | — | — | CN | disclosed |
| CN-101326275-B | Multifunctional ionic liquid composition | UNIV ALABAMA | 2013-06-05 | — | — | CN | disclosed |
| CN-101326275-A | Multifunctional ionic liquid composition | UNIV ALABAMA (US) | 2008-12-17 | — | — | CN | disclosed |
| CN-1251993-A | Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections | SEARLE & CO (US) | 2000-05-03 | — | — | CN | disclosed |
| US-5534129-A | Cyanidic-alkaline baths for the galvanic deposition of copper-tin alloy coatings, uses thereof, and metallic bases coated with said copper-tin alloy coating | DEGUSSA AKTIENGESELLSCHAFT (DE) | 1996-07-09 | — | — | US | disclosed |
| US-5006329-A | Radioactive tagged compounds and method for the treatment of metastatic bone cancer | CADEMA MEDICAL PRODUCTS, INC. (US) | 1991-04-09 | — | — | US | disclosed |
| EP-0419264-A2 | Aminophosphinates and polymers thereof and their use in detergent compositions | Albright & Wilson Limited (GB) | 1991-03-27 | — | — | EP | disclosed |
| US-4762649-A | WATER TREATMENT, ANTISCALING, ANTICORROSION | MONSANTO COMPANY (US) | 1988-08-09 | — | — | US | disclosed |
| US-4719031-A | ANTISCALE | MONSANTO COMPANY (US) | 1988-01-12 | — | — | US | disclosed |
| US-4663432-A | ANTISCALING, CORROSION RESISTANCE | MONSANTO COMPANY (US) | 1987-05-05 | — | — | US | disclosed |
| US-4605474-A | Alkaline cyanide bath for electrolytic deposition of copper-tin-alloy coatings | HOFFACKER GERD (DE) | 1986-08-12 | — | — | US | disclosed |
| US-4565608-A | Alkaline cyanide bath for electrolytic deposition of copper-tin-alloy coatings | DEGUSSA AKTIENGESELLSCHAFT (DE) | 1986-01-21 | — | — | US | disclosed |
| US-4254114-A | Control of pyrophosphate microorganisms with organophosphonates | THE PROCTOR & GAMBLE COMPANY (US) | 1981-03-03 | — | — | US | disclosed |