Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.42 |
| ▸ | MGMT | P16455 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13622014 | 0.93 | MAPT (0.48) | MAPTNR1I2AHRGSK3AGSK3B | |
| SCHEMBL4610548 | 0.81 | KCNH3 (0.43) | SMN1; SMN2L3MBTL1KCNH3ADRA1DADRA1A | |
| SCHEMBL13752395 | 0.78 | MAPT (0.38) | MAPTNR1I2AHRGSK3AGSK3B | |
| SCHEMBL13743141 | 0.75 | MGMT (0.39) | MAPTMGMTKMT2ANPSR1POLB | |
| SCHEMBL13622016 | 0.74 | KCNH3 (0.44) | MAPTKMT2AMEN1HPGDL3MBTL1 | |
| SCHEMBL4237910 | 0.74 | NR1I2 (0.40) | MAPTNR1I2AHRGSK3AGSK3B | |
| SCHEMBL4236100 | 0.74 | ALDH1A1 (0.51) | MAPTNR1I2AHRGSK3AGSK3B | |
| SCHEMBL4776209 | 0.73 | LMNA (0.41) | MAPTMGMTSMN1; SMN2LMNAHPGD | |
| SCHEMBL4794120 | 0.73 | NCF1 (0.40) | MAPTMGMTKMT2APOLBSMN1; SMN2 | |
| SCHEMBL4795307 | 0.73 | MAPT (0.39) | MAPTMGMTKMT2ANPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090209522-A1 | Heterocyclic Non-Peptide GNRH Antagonists | TAKEDA CAMBRIDGE LIMITED (GB) | 2009-08-20 | — | — | US | disclosed |
| US-20080261918-A1 | Silicon Compounds and Their Use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-10-23 | — | — | US | disclosed |
| US-20080261918-A1 | Silicon Compounds and Their Use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-10-23 | — | — | US | disclosed |
| EP-1824863-B1 | SILICON COMPOUNDS AND THEIR USE | TAKEDA CAMBRIDGE LTD (GB) | 2008-10-08 | — | — | EP | disclosed |
| CN-101107259-A | Silicon compounds and their use | TAKEDA CAMBRIDGE LTD (GB) | 2008-01-16 | — | — | CN | disclosed |
| EP-1824863-A1 | SILICON COMPOUNDS AND THEIR USE | Takeda Cambridge Limited (GB) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006064277-A1 | SILICON COMPOUNDS AND THEIR USE | TAKEDA CAMBRIDGE LIMITED (GB) | 2006-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090209522-A1 | Heterocyclic Non-Peptide GNRH Antagonists | GNRHR, GHRHR, FSHR | MAPT 4754/4885NR1I2 253/4885AHR 151/4885 |
| US-20080261918-A1 | Silicon Compounds and Their Use | SOST, SIK2, SCLY | MAPT 1574/4885NR1I2 946/4885AHR 1227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.