Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 3/20 | 0.54 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.51 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 1/20 | 0.44 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.44 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.44 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.44 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.44 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4618216 | 0.86 | KMT2A (0.55) | CCR2VCAM1KIF18AHTTMAPT | |
| SCHEMBL4618632 | 0.81 | ABCC9 (0.47) | CCR2VCAM1HTTMAPTLMNA | |
| SCHEMBL4617825 | 0.80 | VCAM1 (0.57) | CCR2VCAM1HSD11B1HTTLMNA | |
| SCHEMBL2653845 | 0.79 | CCR2 (0.55) | CCR2VCAM1KIF18AHTTMAPT | |
| SCHEMBL4617109 | 0.79 | HSD11B1 (0.52) | HSD11B1MAPTLMNAALDH1A1EPAS1 | |
| SCHEMBL4673628 | 0.78 | CCR2 (0.52) | CCR2VCAM1ALDH1A1KIF11TDP1 | |
| SCHEMBL4617061 | 0.78 | HSD11B1 (0.54) | HSD11B1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL15307418 | 0.76 | KIF18A (0.64) | VCAM1KIF18AHSD11B1HTTMAPT | |
| SCHEMBL4615874 | 0.76 | PKM (0.51) | CCR2VCAM1HSD11B1MAPTLMNA | |
| SCHEMBL4617928 | 0.76 | KMT2A (0.54) | CCR2VCAM1KIF18AHSD11B1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879859-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-23 | — | — | EP | disclosed |
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | disclosed |
| WO-2006124875-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | WYETH (US) | 2006-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | SFRP1, SOS1, FZD7 | CCR2 3674/4885VCAM1 2183/4885KIF18A 4175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.