Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9467374 | 0.86 | KDM4E (0.43) | MTNR1AMTNR1BKDM4EUSP2ALDH1A1 | |
| SCHEMBL9722210 | 0.82 | MTNR1A (0.40) | MTNR1AMTNR1BKDM4EUSP2ALDH1A1 | |
| SCHEMBL6978852 | 0.81 | CA2 (0.45) | MTNR1AMTNR1BBCHEMAOAMAOB | |
| SCHEMBL14143008 | 0.81 | CA2 (0.45) | MTNR1AMTNR1BBCHEMAOAMAOB | |
| SCHEMBL11845112 | 0.79 | HTR2A (0.44) | KDM4EUSP2ALDH1A1LMNAMMP9 | |
| SCHEMBL22996229 | 0.78 | BCHE (0.46) | MTNR1AMTNR1BBCHESIGMAR1HTR6 | |
| SCHEMBL22932054 | 0.77 | BCHE (0.44) | MTNR1AMTNR1BBCHESIGMAR1HTR6 | |
| SCHEMBL18616383 | 0.77 | SIGMAR1 (0.48) | MTNR1AMTNR1BBCHESIGMAR1HTR6 | |
| SCHEMBL22400051 | 0.77 | BCHE (0.45) | MTNR1AMTNR1BBCHESIGMAR1HTR6 | |
| SCHEMBL6758153 | 0.76 | BCHE (0.59) | MTNR1AMTNR1BBCHESIGMAR1HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464641-B1 | 4-Phenyl-piperazinyl, -piperidinyl and tetrahydropyridyl derivatives as dopamine D4 antagonists | LUNDBECK & CO AS H (DK) | 2008-05-14 | — | — | EP | disclosed |
| US-7223765-B2 | 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives | H. LUNDBECK A/S (DK) | 2007-05-29 | — | — | US | disclosed |
| CN-1803784-A | 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives | LUNDBECK CO AS H (DK) | 2006-07-19 | — | — | CN | disclosed |
| US-7074796-B2 | 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives | H. LUNDBECK A/S (DK) | 2006-07-11 | — | — | US | disclosed |
| US-20060148815-A1 | 4-Phenyl-1-piperazinyl, -piperidinyl and-tetrahydropyridyl derivatives | H. LUNDBECK A/S (DK) | 2006-07-06 | — | — | US | disclosed |
| CN-1244577-C | 4-phenyl-1-piperazinyl, -piperidinyl and-tetrahydropyridinyl derivatives | LUNDBECK & CO AS H (DK) | 2006-03-08 | — | — | CN | disclosed |
| EP-1464641-A1 | 4-Phenyl-piperazinyl, -piperidinyl and tetrahydropyridyl derivatives as dopamine D4 antagonists | H. Lundbeck A/S (DK) | 2004-10-06 | — | — | EP | disclosed |
| CN-1434819-A | 4-phenyl-1-piperazinyl, -piperidinyl and-tetrahydropyridinyl derivatives | LUNDBECK & CO AS H (DK) | 2003-08-06 | — | — | CN | disclosed |
| US-20030027832-A1 | 4-Phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives | H. LUNDBECK A/S (DK) | 2003-02-06 | — | — | US | disclosed |
| EP-1246817-A1 | 4-PHENYL-1-PIPERAZINYL, -PIPERIDINYL AND -TETRAHYDROPYRIDYL DERIVATIVES | H. Lundbeck A/S (DK) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001049679-A1 | 4-PHENYL-1-PIPERAZINYL, -PIPERIDINYL AND -TETRAHYDROPYRIDYL DERIVATIVES | H. LUNDBECK A/S (DK) | 2001-07-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060148815-A1 | 4-Phenyl-1-piperazinyl, -piperidinyl and-tetrahydropyridyl derivatives | OPRD1, VDR, GPR4 | MTNR1A 60/4885MTNR1B 108/4885BCHE 3993/4885 |
| US-20030027832-A1 | 4-Phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives | OPRD1, DRD3, DRD2 | MTNR1A 133/4885MTNR1B 404/4885BCHE 3739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.