Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 2/20 | 0.35 |
| ▸ | MMP13 | P45452 | 2/20 | 0.35 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.34 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6231818 | 0.89 | ACLY (0.45) | ACLYTDP1HSD11B1LMNAMAPK1 | |
| SCHEMBL6232295 | 0.86 | LMNA (0.41) | ACLYTDP1HSD11B1LMNAMAPK1 | |
| SCHEMBL6233316 | 0.76 | HSD11B1 (0.39) | TDP1HSD11B1LMNAMCL1MAPT | |
| SCHEMBL4646022 | 0.73 | CNR1 (0.38) | TDP1HSD11B1MAPK1MAPTENPP3 | |
| SCHEMBL27629193 | 0.69 | MCL1 (0.53) | TDP1LMNAMAPK1MCL1MAPT | |
| SCHEMBL2721044 | 0.69 | MCL1 (0.49) | ACLYLMNAMAPK1MCL1MAPT | |
| SCHEMBL6151703 | 0.65 | LMNA (0.53) | ACLYTDP1LMNAMAPK1MCL1 | |
| SCHEMBL1665211 | 0.65 | TDP1 (0.64) | TDP1MAPTENPP3ENPP1ALDH1A1 | |
| SCHEMBL15700018 | 0.64 | LMNA (0.41) | ACLYTDP1LMNAMAPK1MCL1 | |
| SCHEMBL12469781 | 0.63 | ACLY (0.76) | ACLYLMNAALDH1A1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1193243-B1 | NOVEL PROCESS FOR PRODUCING BICYCLIC AMINO ALCOHOL | SHIONOGI & CO (JP) | 2008-08-13 | — | — | EP | disclosed |
| US-7214832-B2 | Processes for the preparation of bicyclic aminoalcohols | SHIONOGI & CO., LTD. (JP) | 2007-05-08 | — | — | US | disclosed |
| EP-1084711-B1 | REMEDIES FOR THE TREATMENT OF ITCHING CONTAINING PGD2 ANTAGONISTS | SHIONOGI & CO (JP) | 2005-05-11 | — | — | EP | disclosed |
| EP-1528060-A1 | Process for preparing 5-hydroxy[b]thiophene-3-carboxylic acid derivatives | SHIONOGI & CO., LTD. (JP) | 2005-05-04 | — | — | EP | disclosed |
| EP-1069123-B1 | PROCESS FOR PRODUCING BENZOTHIOPHENECARBOXYLIC ACID AMIDE DERIVATIVES | SHIONOGI & CO (JP) | 2004-11-10 | — | — | EP | disclosed |
| US-20040171882-A1 | Novel processes for the preparation of bicyclic aminoalcohols | HONMA TSUNETOSHI (JP) | 2004-09-02 | — | — | US | disclosed |
| US-6723857-B1 | NORPINONE TO ITS BENZOTHIOPHENE CARBOXAMIDE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2004-04-20 | — | — | US | disclosed |
| US-20030027854-A1 | Methods for the treatment of itching comprising administering PGD2 receptor antagonists | SHIONOGI & CO., LTD. | 2003-02-06 | — | — | US | disclosed |
| US-6506789-B2 | For prophylaxis and therapy of itching derived from contact dermatitis, allergic conjunctivitis, urticaria, atopic dermatitis | SHIONOGI & CO., LTD. (JP) | 2003-01-14 | — | — | US | disclosed |
| US-6495702-B2 | SPECIFIC PGD2 ANTAGONISTS; STARTING MATERIALS FOR PRODUCING DRUGS | SHIONOGI & CO., LTD. (JP) | 2002-12-17 | — | — | US | disclosed |
| US-20020058693-A1 | Methods for the treatment of itching comprising administering PGD2 receptor antagonists | ARIMURA AKINORI (JP) | 2002-05-16 | — | — | US | disclosed |
| EP-1193243-A1 | NOVEL PROCESS FOR PRODUCING BICYCLIC AMINO ALCOHOL | SHIONOGI & CO., LTD. (JP) | 2002-04-03 | — | — | EP | disclosed |
| US-20020026061-A1 | Process for preparing 5-hydroxybenzo [b] thiophene-3-carboxylic acid derivatives | HONMA TSUNETOSHI (JP) | 2002-02-28 | — | — | US | disclosed |
| US-6346628-B1 | REACTING 4-MERCAPTOPHENOL WITH A PROPARYGL GOUP AND PROTECTION OF HYDROXYL GROUP, OXIDIZING THE PRODUCT, AND THERMAL REARRANGEMENT TO CYCLIZE, FOLLOWED BY FURTHER OXIDATION | SHIONOGI & CO., LTD. (JP) | 2002-02-12 | — | — | US | disclosed |
| US-20020016476-A1 | PROCESS FOR PREPARING 5-HYDROXYBENZO [B] THIOPHENE-3-CARBOXYLIC ACID DERIVATIVES | HONMA TSUNETOSHI (JP) | 2002-02-07 | — | — | US | disclosed |
| US-6320060-B1 | INTRODUCING PROPARGYL GROUP INTO 4-MERCAPTOPHENOL, PROTECTING HYDROXYL GROUP, OXIDIZING COMPOUND, SUBJECTING TO THERMAL REARRANGEMENT REACTION, SUBJECTING TO STEPWISE OXIDATION OF HYDROXYMETHYL GROUP AND OPTIONALLY DEPROTECTION | SHIONOGI & CO., LTD. (JP) | 2001-11-20 | — | — | US | disclosed |
| EP-1084711-A1 | REMEDIES FOR ITCHING CONTAINING PGD 2? ANTAGONISTS | SHIONOGI & CO., LTD. (JP) | 2001-03-21 | — | — | EP | disclosed |
| EP-1069123-A1 | PROCESS FOR PRODUCING BENZOTHIOPHENECARBOXYLIC ACID AMIDE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2001-01-17 | — | — | EP | disclosed |
| EP-1069122-A1 | PROCESS FOR PRODUCING 5-HYDROXYBENZO b]THIOPHENE-3-CARBOXYLIC ACID DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2001-01-17 | — | — | EP | disclosed |
| US-6083974-A | BENZOTHIOPHENECARBOXAMIDE CONTAINING NORPINANE RING IS USEFUL FOR PREVENTING NASAL BLOCKAGE | SHIONOGI & CO., LTD. (JP) | 2000-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020016476-A1 | PROCESS FOR PREPARING 5-HYDROXYBENZO [B] THIOPHENE-3-CARBOXYLIC ACID DERIVATIVES | HPD, PTGDR2, PTGS2 | ACLY 2844/4885TDP1 3016/4885HSD11B1 164/4885 |
| US-20040171882-A1 | Novel processes for the preparation of bicyclic aminoalcohols | DOHH, OXER1, XDH | ACLY 1010/4885TDP1 2618/4885HSD11B1 731/4885 |
| US-20020026061-A1 | Process for preparing 5-hydroxybenzo [b] thiophene-3-carboxylic acid derivatives | HPD, PTGDR2, PTGS2 | ACLY 2844/4885TDP1 3016/4885HSD11B1 164/4885 |
| US-20020058693-A1 | Methods for the treatment of itching comprising administering PGD2 receptor antagonists | HRH2, PTGER2, PTGDR2 | ACLY 2696/4885TDP1 4594/4885HSD11B1 763/4885 |
| US-20030027854-A1 | Methods for the treatment of itching comprising administering PGD2 receptor antagonists | HRH2, PTGER2, PTGDR2 | ACLY 2696/4885TDP1 4594/4885HSD11B1 763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.