SCHEMBL4643793

SCHEMBL4643793

O=S(=O)(OS(c1ccccc1)(c1ccccc1)c1ccc(-c2ccccc2)cc1)C(F)(F)F

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 2/20 0.46
CA2 P00918 2/20 0.46
CA9 Q16790 2/20 0.46
CA12 O43570 1/20 0.46
MMP2 P08253 1/20 0.40
MMP7 P09237 1/20 0.40
MMP14 P50281 1/20 0.40
KIF11 P52732 1/20 0.39
PTPN1 P18031 2/20 0.39
GAA P10253 2/20 0.39
HSD11B1 P28845 1/20 0.39
MEN1 O00255 1/20 0.39
MAPT P10636 1/20 0.39
MAPK1 P28482 1/20 0.39
HTT P42858 1/20 0.39
RECQL P46063 1/20 0.39
KMT2A Q03164 1/20 0.39
PARL Q9H300 1/20 0.39
ALDH1A1 P00352 1/20 0.39
PTGS2 P35354 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL37033 0.91 HTR6 (0.42) CA1CA2CA9CA12MMP2
SCHEMBL3130157 0.86 PKM (0.46) HSD11B1MEN1MAPK1KMT2AALDH1A1
SCHEMBL503373 0.86 PKM (0.46) HSD11B1MEN1MAPK1KMT2AALDH1A1
SCHEMBL147485 0.84 IDO1 (0.40) CA1CA2CA9CA12MMP2
SCHEMBL3139517 0.84 TDP1 (0.46) CA1CA2CA9CA12GAA
SCHEMBL1261245 0.84 HSD11B1 (0.45) CA1CA2CA9KIF11HSD11B1
SCHEMBL3136958 0.84 HTT (0.45) CA1CA2CA9CA12GAA
SCHEMBL36148 0.84 HTT (0.45) CA1CA2CA9CA12GAA
SCHEMBL444803 0.84 PTGS2 (0.44) HSD11B1PTGS2
SCHEMBL548280 0.84 ESR1 (0.42) CA1CA2CA9CA12MMP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1443042-B1 HYBRID ONIUM SALT WAKO PURE CHEM IND LTD (JP) 2008-08-13 EP disclosed
US-7101918-B2 Hybrid type onium salt WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) 2006-09-05 US disclosed
US-20050020710-A1 Hybrid onium salt WAKO PURE CHEMICALS INDUSTRIES, LTD. (JP) 2005-01-27 US disclosed
EP-1443042-A1 HYBRID ONIUM SALT Wako Pure Chemical Industries, Ltd. (JP) 2004-08-04 EP disclosed